The White House on Friday announced the departure of Ron Klain as US President Joe Biden's chief of staff after two years of service.
Long-time Biden staffer Jeffrey Zients will succeed him in the role.
“I’m confident that Jeff will continue Ron’s example of smart, steady leadership, as we continue to work hard every day for the people we were sent here to serve,” Mr Biden said in a statement.
Mr Zients led the Biden administration's response to the coronavirus pandemic and oversaw the largest vaccination programme in American history with the roll-out of Covid-19 vaccines.
Before the pandemic, he was known for rebooting the national HealthCare.gov website after its mismanaged launch during Barack Obama's administration.
He will enter a Democratic White House facing challenges from a Republican-led House of Representatives and a federal investigation into classified documents from Mr Biden's time as vice president and US senator that were found in his home and former office.
Mr Klain said it was the “right time” for a transition.
“The halfway point of your first term — with two successful years behind us, and key decisions on the next two years ahead — is the right time for this team to have fresh leadership,” he said in a statement.
“I have served longer than eight of the last nine chiefs of staff, and have given this job my all; now it is time for someone else to take it on.”
Mr Klain helped guide the White House through a presidential transition after the January 6, 2021, insurrection as well as the early days of the pandemic.
Active on Twitter, he has lauded the Biden administration's successes in job creation, lowering healthcare costs, gun control legislation, climate change action and infrastructure investments.
The Associated Press cited him as telling staff in a letter last week: “Although much work remains ahead, as we look back on these two years, I am awestruck at what this team has done and how you have done it.”
Reports say Mr Klain will depart his position shortly after Mr Biden's State of the Union address to Congress in early February.
Killing of Qassem Suleimani
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Messi at the Copa America
2007 – lost 3-0 to Brazil in the final
2011 – lost to Uruguay on penalties in the quarter-finals
2015 – lost to Chile on penalties in the final
2016 – lost to Chile on penalties in the final
The bio
Who inspires you?
I am in awe of the remarkable women in the Arab region, both big and small, pushing boundaries and becoming role models for generations. Emily Nasrallah was a writer, journalist, teacher and women’s rights activist
How do you relax?
Yoga relaxes me and helps me relieve tension, especially now when we’re practically chained to laptops and desks. I enjoy learning more about music and the history of famous music bands and genres.
What is favourite book?
The Perks of Being a Wallflower - I think I've read it more than 7 times
What is your favourite Arabic film?
Hala2 Lawen (Translation: Where Do We Go Now?) by Nadine Labaki
What is favourite English film?
Mamma Mia
Best piece of advice to someone looking for a career at Google?
If you’re interested in a career at Google, deep dive into the different career paths and pinpoint the space you want to join. When you know your space, you’re likely to identify the skills you need to develop.