Delta AY.4.2 mutation accounts for more than 10% of England's Covid cases


Laura O'Callaghan
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A derivative of the Delta variant of Covid-19 that is more infectious than the original strain has spread to account for one in 10 infections in England.

The AY.4.2 mutation has been increasing at a rate of 2.8 per cent per day since September, figures compiled by researchers in Imperial College London’s long-running React-1 study show.

British health officials are monitoring the strain as a “variant under investigation”.

Experts tested about 100,000 people selected randomly across most age groups and regions for coronavirus between October 19 and November 5 and said 11.8 per cent carried the variant.

Scientists said people infected with AY.4.2 are more likely to be asymptomatic compared to those who infected with other Covid-19 variants.

The study showed that one third of people who carry AY.4.2 displayed typical coronavirus symptoms such as a persistent cough, loss or change in taste and smell, and a fever. This compared to 46 per cent of people infected with the original Delta variant.

Prof Paul Elliott, director of the study, said the data suggested the strain was more infectious that the common Delta variant.

"Why it is more transmissible we don't know,” he said. “It does seem to be less symptomatic, which is a good thing.”

Christl Donnelly, professor of statistical epidemiology at Imperial College London, said the lower rate of infected people displaying symptoms could lead to an increase in transmission in England.

“It is absolutely the case that if people are waiting for symptoms to do a test and to therefore identify that they are infected and therefore cut back their contacts, being asymptomatic may facilitate transmission, for example,” she said.

“It is asymptomatic transmission that really can make the difference between what’s relatively easily containable and what needs vaccination.”

Researchers say the observational nature of survey data and the relatively small proportion of unvaccinated adults calls into question the comparability of vaccinated and unvaccinated groups.

However, they found that booster vaccines for eligible adults and the inoculation of children aged 12 and over were associated with a lower infection risk.

Experts at Imperial College London said these programmes should therefore remain a high priority for the UK government, which sets Covid-19 rules for England.

Devolved administrations in Scotland, Wales and Northern Ireland have the power to make their own decisions but often follow England in many areas.

The study has been released as a preprint that has not been through peer review and is not published in a journal.

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The major Hashd factions linked to Iran:

Badr Organisation: Seen as the most militarily capable faction in the Hashd. Iraqi Shiite exiles opposed to Saddam Hussein set up the group in Tehran in the early 1980s as the Badr Corps under the supervision of the Iran Revolutionary Guards Corps (IRGC). The militia exalts Iran’s Supreme Leader Ali Khamenei but intermittently cooperated with the US military.

Saraya Al Salam (Peace Brigade): Comprised of former members of the officially defunct Mahdi Army, a militia that was commanded by Iraqi cleric Moqtada Al Sadr and fought US and Iraqi government and other forces between 2004 and 2008. As part of a political overhaul aimed as casting Mr Al Sadr as a more nationalist and less sectarian figure, the cleric formed Saraya Al Salam in 2014. The group’s relations with Iran has been volatile.

Kataeb Hezbollah: The group, which is fighting on behalf of the Bashar Al Assad government in Syria, traces its origins to attacks on US forces in Iraq in 2004 and adopts a tough stance against Washington, calling the United States “the enemy of humanity”.

Asaeb Ahl Al Haq: An offshoot of the Mahdi Army active in Syria. Asaeb Ahl Al Haq’s leader Qais al Khazali was a student of Mr Al Moqtada’s late father Mohammed Sadeq Al Sadr, a prominent Shiite cleric who was killed during Saddam Hussein’s rule.

Harakat Hezbollah Al Nujaba: Formed in 2013 to fight alongside Mr Al Assad’s loyalists in Syria before joining the Hashd. The group is seen as among the most ideological and sectarian-driven Hashd militias in Syria and is the major recruiter of foreign fighters to Syria.

Saraya Al Khorasani:  The ICRG formed Saraya Al Khorasani in the mid-1990s and the group is seen as the most ideologically attached to Iran among Tehran’s satellites in Iraq.

(Source: The Wilson Centre, the International Centre for the Study of Radicalisation)

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There are a number of speciality art bookshops in the UAE.

In Dubai, The Lighthouse at Dubai Design District has a wonderfully curated selection of art and design books. Alserkal Avenue runs a pop-up shop at their A4 space, and host the art-book fair Fully Booked during Art Week in March. The Third Line, also in Alserkal Avenue, has a strong book-publishing arm and sells copies at its gallery. Kinokuniya, at Dubai Mall, has some good offerings within its broad selection, and you never know what you will find at the House of Prose in Jumeirah. Finally, all of Gulf Photo Plus’s photo books are available for sale at their show. 

In Abu Dhabi, Louvre Abu Dhabi has a beautiful selection of catalogues and art books, and Magrudy’s – across the Emirates, but particularly at their NYU Abu Dhabi site – has a great selection in art, fiction and cultural theory.

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UPI facts

More than 2.2 million Indian tourists arrived in UAE in 2023
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Updated: November 18, 2021, 12:44 PM`