The technology behind the Oxford AstraZeneca Covid-19 vaccination is being tested as a possible vaccine against cancer with the launch of human trials of the research.
The development of a two-dose “cancer vaccine” that targets tumours in people comes after successful test results in mice showed an increase in the number of anti-tumour cells attacking cancerous growths. Survival rates also increased when coupled with other anti-cancer therapy.
Later this year, the first human trials will take place involving 80 patients with non-small cell lung cancer.
The study, which was done by Prof Benoit van den Eynde's group at the Ludwig Institute for Cancer Research, in collaboration with co-authors Prof Adrian Hill and Dr Irina Redchenko at the Jenner Institute, is published in the Journal for ImmunoTherapy of Cancer.
The Oxford team behind the study said it would revolutionise cancer treatment.
"We knew from our previous research that melanoma antigen gene-type proteins act like red flags on the surface of cancer cells to attract immune cells that destroy tumours,” said Prof Eynde, professor of tumour immunology at the University of Oxford.
These "proteins have an advantage over other cancer antigens as vaccine targets since they are present on a wide range of tumour types", Prof Eynde said. "This broadens the potential benefit of this approach to people with many different types of cancer."
Working in similar ways to the Oxford AstraZeneca Covid-19 inoculation, the cancer vaccine uses the same technology to transport a piece of genetic code into a person’s cells through a harmless virus.
In the case of the Covid-19 vaccine, the recipient’s cells make replicas of spike proteins that train the immune system to fight off the real virus.
This new two-shot cancer vaccine also uses a harmless virus as a vector to carry a genetic code that makes the body respond and mobilise against the proteins on the surface of cancer cells.
Squid Game season two
Director: Hwang Dong-hyuk
Stars: Lee Jung-jae, Wi Ha-joon and Lee Byung-hun
Rating: 4.5/5
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Living in...
This article is part of a guide on where to live in the UAE. Our reporters will profile some of the country’s most desirable districts, provide an estimate of rental prices and introduce you to some of the residents who call each area home.
Killing of Qassem Suleimani
Killing of Qassem Suleimani
New UK refugee system
- A new “core protection” for refugees moving from permanent to a more basic, temporary protection
- Shortened leave to remain - refugees will receive 30 months instead of five years
- A longer path to settlement with no indefinite settled status until a refugee has spent 20 years in Britain
- To encourage refugees to integrate the government will encourage them to out of the core protection route wherever possible.
- Under core protection there will be no automatic right to family reunion
- Refugees will have a reduced right to public funds
Going grey? A stylist's advice
If you’re going to go grey, a great style, well-cared for hair (in a sleek, classy style, like a bob), and a young spirit and attitude go a long way, says Maria Dowling, founder of the Maria Dowling Salon in Dubai.
It’s easier to go grey from a lighter colour, so you may want to do that first. And this is the time to try a shorter style, she advises. Then a stylist can introduce highlights, start lightening up the roots, and let it fade out. Once it’s entirely grey, a purple shampoo will prevent yellowing.
“Get professional help – there’s no other way to go around it,” she says. “And don’t just let it grow out because that looks really bad. Put effort into it: properly condition, straighten, get regular trims, make sure it’s glossy.”
David Haye record
Total fights: 32
Wins: 28
Wins by KO: 26
Losses: 4
Specs
Engine: 51.5kW electric motor
Range: 400km
Power: 134bhp
Torque: 175Nm
Price: From Dh98,800
Available: Now
Teachers' pay - what you need to know
Pay varies significantly depending on the school, its rating and the curriculum. Here's a rough guide as of January 2021:
- top end schools tend to pay Dh16,000-17,000 a month - plus a monthly housing allowance of up to Dh6,000. These tend to be British curriculum schools rated 'outstanding' or 'very good', followed by American schools
- average salary across curriculums and skill levels is about Dh10,000, recruiters say
- it is becoming more common for schools to provide accommodation, sometimes in an apartment block with other teachers, rather than hand teachers a cash housing allowance
- some strong performing schools have cut back on salaries since the pandemic began, sometimes offering Dh16,000 including the housing allowance, which reflects the slump in rental costs, and sheer demand for jobs
- maths and science teachers are most in demand and some schools will pay up to Dh3,000 more than other teachers in recognition of their technical skills
- at the other end of the market, teachers in some Indian schools, where fees are lower and competition among applicants is intense, can be paid as low as Dh3,000 per month
- in Indian schools, it has also become common for teachers to share residential accommodation, living in a block with colleagues
Most sought after workplace benefits in the UAE
- Flexible work arrangements
- Pension support
- Mental well-being assistance
- Insurance coverage for optical, dental, alternative medicine, cancer screening
- Financial well-being incentives
Most wanted allegations
- Benjamin Macann, 32: involvement in cocaine smuggling gang.
- Jack Mayle, 30: sold drugs from a phone line called the Flavour Quest.
- Callum Halpin, 27: over the 2018 murder of a rival drug dealer.
- Asim Naveed, 29: accused of being the leader of a gang that imported cocaine.
- Calvin Parris, 32: accused of buying cocaine from Naveed and selling it on.
- John James Jones, 31: allegedly stabbed two people causing serious injuries.
- Callum Michael Allan, 23: alleged drug dealing and assaulting an emergency worker.
- Dean Garforth, 29: part of a crime gang that sold drugs and guns.
- Joshua Dillon Hendry, 30: accused of trafficking heroin and crack cocain.
- Mark Francis Roberts, 28: grievous bodily harm after a bungled attempt to steal a £60,000 watch.
- James ‘Jamie’ Stevenson, 56: for arson and over the seizure of a tonne of cocaine.
- Nana Oppong, 41: shot a man eight times in a suspected gangland reprisal attack.
