Syrian President Bashar Al Assad on Thursday dismissed Imad Khamis as prime minister and appointed Water Minister Hussein Arnous in his place, according to a short statement on state media.
No reason was given for the removal of Mr Khamis, who held the post since 2016.
Under the Assad family regime, Syria's prime ministers are appointed from the Sunni majority, but the post is largely inconsequential as all power is held by an inner circle dominated the president's Alawite minority.
Mr Al Assad's sudden move appears to be designed to absorb discontent among loyalists as regime-held regions lurch off an economic cliff with the currency in freefall.
The collapse in the Syrian pound contributed to sporadic demonstrations breaking out this week in the Druze majority governorate of Suweida. The regime considers the Druze a loyalist fellow minority.
An increasingly public feud between the president and his cousin, the oligarch Rami Makhlouf, exposed the wealth of the inner circle at a time of severe economic hardship that affects the regime's core support base comprising Alawites and other minorities.
The sharp fall in the Syrian currency in recent weeks to 2,450 pounds per dollar has pushed even the middle class into hardship with the cost of basic commodities rising rapidly. The pound was trading at 50 pounds to the dollar when a public revolt against Assad family rule broke out in March 2011.
Mr Arnous, born in 1953, has served as water minister since November 2018 and was previously the public works and housing minister.
State media said Mr Al Assad had tasked Mr Arnous with the duties of the prime minister as well as his current responsibility as water minister.
Before he became prime minister, Mr Khamis served as electricity minister and was sanctioned by the European Union in 2012 for his role in using power cuts to punish and silence the 2011 uprising.
The peaceful revolt had militarised by the end of the year, largely in reaction to the abduction and killing of thousands of demonstrators by the security forces. The country fractured during the ensuing civil war into Russian, US, Iranian and Turkish spheres of influence.
Syrian war in pictures
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Anxiety and work stress major factors
Anxiety, work stress and social isolation are all factors in the recogised rise in mental health problems.
A study UAE Ministry of Health researchers published in the summer also cited struggles with weight and illnesses as major contributors.
Its authors analysed a dozen separate UAE studies between 2007 and 2017. Prevalence was often higher in university students, women and in people on low incomes.
One showed 28 per cent of female students at a Dubai university reported symptoms linked to depression. Another in Al Ain found 22.2 per cent of students had depressive symptoms - five times the global average.
It said the country has made strides to address mental health problems but said: “Our review highlights the overall prevalence of depressive symptoms and depression, which may long have been overlooked."
Prof Samir Al Adawi, of the department of behavioural medicine at Sultan Qaboos University in Oman, who was not involved in the study but is a recognised expert in the Gulf, said how mental health is discussed varies significantly between cultures and nationalities.
“The problem we have in the Gulf is the cross-cultural differences and how people articulate emotional distress," said Prof Al Adawi.
“Someone will say that I have physical complaints rather than emotional complaints. This is the major problem with any discussion around depression."
Daniel Bardsley