Uber has lost its permit to operate in London after the transport regulator in the UK capital declared the company "not fit and proper" to hold a licence.
Transport for London said on Monday that a "pattern of failures had placed passenger safety and security at risk".
The regulator said breaches by Uber included unauthorised drivers exploiting vulnerabilities in the app to carry thousands of passengers.
Uber’s licence in London is due to expire on Monday at midnight local time.
Uber Technologies Inc's shares fell 4.3 per cent as US markets opened.
Helen Chapman, Director of Licensing, Regulation and Charging at TfL, said: "Safety is our absolute top priority. While we recognise Uber has made improvements, it is unacceptable that Uber has allowed passengers to get into minicabs with drivers who are potentially unlicensed and uninsured.
“It is clearly concerning that these issues arose, but it is also concerning that we cannot be confident that similar issues won’t happen again in future."
Uber has 21 days to appeal against the decision, during which time it will be able to continue to operate in London.
Uber has been engaged in a battle with London's transport officials since 2017 after TfL refused to renew its licence, citing failures in the San Francisco company's approach to reporting serious criminal offences and driver background checks.
Uber appealed the decision and was granted a 15-month licence in 2018, which expired in September this year. The company was then granted a further two-month extension.
The company said it would introduce measures to improve driver and passenger safety, including a discrimination button enabling drivers and riders to report abuse, enhanced safety training for drivers and a direct connection to the emergency services.
Uber described the decision as "extraordinary and wrong". The company claims to have audited every driver in London over the past two months.
Uber's chief executive Dara Khosrowshahi wrote on Twitter: "We understand we’re held to a high bar, as we should be. But this TfL decision is just wrong.
"Over the last 2 years we have fundamentally changed how we operate in London. We have come very far — and we will keep going, for the millions of drivers and riders who rely on us."
However, Mayor of London Sadiq Khan said in the past few months, it had been established that 14,000 Uber journeys had been conducted fraudulently with unauthorised drivers uploading their photos to other drivers' accounts.
"I know this decision may be unpopular with Uber users but their safety is of paramount concern," Mr Khan said.
"Regulations are there to keep Londoners safe, and fully complying with TfL's strict standards is essential if private hire operators want a licence to operate in London."
The company has fired back, pointing out that Tfl had found it fit and proper in its most recent license renewal in September.
Jeremy Corbyn, leader of the main opposition party Labour, said: "We want innovation but not at the expense of people's safety. Sadiq Khan is right. Like everyone else, Uber must play by the rules."
"A Labour government will not tolerate companies which exploit their workers, don't pay their fair share of taxes and disregard passengers' safety," he added.
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Director: Shonali Bose
Cast: Priyanka Chopra Jonas, Farhan Akhtar, Zaira Wasim, Rohit Saraf
Three stars
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Rating: 3/5
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Price, base: From Dh57,000
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RESULTS
6.30pm: Maiden Dh 165,000 1,600m
Winner: Superior, Connor Beasley (jockey), Ahmad bin Harmash (trainer)
7.05pm: Handicap Dh 185,000 2,000m
Winner: Tried And True, Pat Dobbs, Doug Watson
7.40pm: Maiden Dh 165,000 1,600m
Winner: Roy Orbison, Fernando Jara, Ali Rashid Al Raihe
8.15pm
Handicap Dh 190,000 1,400m
Winner: Taamol, Dane O’Neill, Ali Rashid Al Raihe
8.50pm
Handicap Dh 175,000 1,600m
Winner: Welford, Richard Mullen, Satish Seemar
9.25pm: Handicap Dh 175,000 1,200m
Winner: Lavaspin, Richard Mullen, Satish Seemar
10pm: Handicap Dh 165,000 1,600m
Winner: Untold Secret, Xavier Ziani, Sandeep Jadhav
Key facilities
- Olympic-size swimming pool with a split bulkhead for multi-use configurations, including water polo and 50m/25m training lanes
- Premier League-standard football pitch
- 400m Olympic running track
- NBA-spec basketball court with auditorium
- 600-seat auditorium
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- Specialist robotics and science laboratories
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- Disruption Lab and Research Centre for developing entrepreneurial skills
Juliot Vinolia’s checklist for adopting alternate-day fasting
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Results
2.30pm Maiden (PA) Dh40,000 1,200m
Winner Lamia, Tadhg O’Shea, Ernst Oertel.
3pm Handicap (PA) Dh40,000 1,000m
Winner Jap Al Afreet, Elione Chaves, Irfan Ellahi.
3.30pm Handicap (PA) Dh40,000 1,700m
Winner MH Tawag, Bernardo Pinheiro, Elise Jeanne.
4pm Handicap (TB) Dh40,000 2,000m
Winner Skygazer, Sandro Paiva, Ali Rashid Al Raihe.
4.30pm The Ruler of Sharjah Cup Prestige (PA) Dh250,000 1,700m
Winner AF Kal Noor, Tadhg O’Shea, Ernst Oertel.
5pm Sharjah Marathon (PA) Dh70,000 2,700m
Winner RB Grynade, Bernardo Pinheiro, Eric Lemartinel.
The biog
Name: Sari Al Zubaidi
Occupation: co-founder of Cafe di Rosati
Age: 42
Marital status: single
Favourite drink: drip coffee V60
Favourite destination: Bali, Indonesia
Favourite book: 100 Years of Solitude