Doctors are being warned to look out for signs of stroke after a woman in her 30s who received the AstraZeneca Covid-19 vaccine died in hospital after a blood clot formed in an artery in her brain.
The patient, a 35-year-old Asian woman, went to hospital six days after her vaccine appointment and died two weeks after being admitted after “extensive haemorrhaging”.
Two others, a white woman, 37, and a 43-year-old Asian man, also suffered strokes but survived.
Experts from University College London and the University of Cambridge studied the cases. Their findings were published in the British Medical Journal.
They emphasised that the cases of stroke are very rare and that stroke is more common in people who catch Covid-19.
However, it is the first time the coronavirus vaccine developed by AstraZeneca is being linked to clots in arteries. It comes months after the drug attracted international headlines after some patients experienced rare blood clots in veins of the brain, called cerebral venous sinus thrombosis.
The UK medicines regulator is recommending that those under 40 should receive a different vaccine, while some European countries stopped using the shot altogether.
Doctors are now being urged to watch out for signs of ischaemic stroke – where arteries supplying the brain become blocked – in people who have received the AstraZeneca vaccine.
Symptoms include weakness along one side of the body, headaches, confusion, loss of vision, and difficulty talking and walking, and manifest within a month of vaccination.
Those who experience the symptoms should be “urgently evaluated” for a very rare syndrome – vaccine-induced thrombosis and thrombocytopenia (VITT).
Experts said there were 309 cases of major thrombosis with low platelet count, suggesting VITT, from more than 30 million doses of the AstraZeneca vaccine administered.
The number of people who experience blood clots from VITT after a Covid-19 vaccine is therefore extremely low, about one per 100,000 doses.
Prof David Werring from UCL, lead author of the study, said doctors need to be vigilant if patients present with typical stroke symptoms.
“Although cerebral venous thrombosis – an uncommon stroke type in clinical practice – is now recognised as being the most frequent presentation of VITT, our study shows that the much more common ischaemic stroke, due to arterial thrombosis blocking blood flow to part of the brain, may also be a presenting feature of vaccine-induced thrombosis,” he said.
Dr June Raine, chief executive of the UK’s Medicines and Healthcare Products Regulatory Agency, said reports of blood clots were being monitored.
“No effective medicine or vaccine is without risk,” she said.
“These specific kinds of blood clots with low platelets reported following Covid-19 vaccine AstraZeneca remain extremely rare and unlikely to occur. Our advice remains that the benefits of the vaccine outweigh the risks in the majority of people.”
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RESULTS
5pm: Maiden | Dh80,000 | 1,600m
Winner: AF Al Moreeb, Tadhg O’Shea (jockey), Ernst Oertel (trainer)
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6pm: Handicap | Dh80,000 | 2,200m
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7pm: Shadwell Farm for Private Owners Handicap | Dh70,000 | 2,200m
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7.30pm: Handicap (TB) | Dh100,000 | 1,600m
Winner: Treasured Times, Bernardo Pinheiro, Rashed Bouresly
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Position: Right Wing
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U16 Age Group
Name: Mehdi Elkhamlichi (Malaga)
Position: Lead Striker
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The Voice of Hind Rajab
Starring: Saja Kilani, Clara Khoury, Motaz Malhees
Director: Kaouther Ben Hania
Rating: 4/5
Huddersfield Town permanent signings:
- Steve Mounie (striker): signed from Montpellier for £11 million
- Tom Ince (winger): signed from Derby County for £7.7m
- Aaron Mooy (midfielder): signed from Manchester City for £7.7m
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- Elias Kachunga (winger): signed for Ingolstadt for £1.1m
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Tamkeen's offering
- Option 1: 70% in year 1, 50% in year 2, 30% in year 3
- Option 2: 50% across three years
- Option 3: 30% across five years
Match info
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1. Fasting
2. Prayer
3. Hajj
4. Shahada
5. Zakat
Wicked: For Good
Director: Jon M Chu
Starring: Ariana Grande, Cynthia Erivo, Jonathan Bailey, Jeff Goldblum, Michelle Yeoh, Ethan Slater
Rating: 4/5
A list of the animal rescue organisations in the UAE
The biog
Favourite film: The Notebook
Favourite book: What I know for sure by Oprah Winfrey
Favourite quote: “Social equality is the only basis of human happiness” Nelson Madela. Hometown: Emmen, The Netherlands
Favourite activities: Walking on the beach, eating at restaurants and spending time with friends
Job: Founder and Managing Director of Mawaheb from Beautiful Peopl
Abu Dhabi GP weekend schedule
Friday
First practice, 1pm
Second practice, 5pm
Saturday
Final practice, 2pm
Qualifying, 5pm
Sunday
Etihad Airways Abu Dhabi Grand Prix (55 laps), 5.10pm
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First Test, Galle International Stadium
July 26-30
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August 3-7
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August 12-16
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August 20
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August 24
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August 27
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August 31
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September 3
T20, R Premadasa Stadium
September 6
MATCH INFO
Hoffenheim v Liverpool
Uefa Champions League play-off, first leg
Location: Rhein-Neckar-Arena, Sinsheim
Kick-off: Tuesday, 10.45pm (UAE)
