Delaying the second dose of Covid-19 vaccines could in some conditions reduce mortality by up to 20 per cent, research published on Wednesday shows.
The vaccines developed by Pfizer-BioNTech and Moderna are both two-dose treatments but there are circumstances when people may benefit from a delayed dose, according to a US study published in The BMJ on Wednesday.
For people under 65, the circumstances include having a one-dose vaccine efficacy of 80 per cent or higher and vaccination rates of 0.1 to 0.3 per cent of the population a day.
“Decision-makers will need to consider their local vaccination rates and weigh the benefits of increasing these rates by delaying a second dose, versus the risks associated with the remaining uncertainty in this strategy," the researchers said.
"These decisions should continue to be re-evaluated as new data become available."
The longer it takes to effectively vaccinate the world, the higher the chance that variant strains will develop with immunity to available drugs.
This has sparked calls for giving priority to single-dose vaccines.
But the assumption that meaningful protection against Covid-19 can be achieved after a single dose of vaccine is the subject of continuing debate.
The US team of researchers set out to measure the effect of delayed second dose vaccine policies on infections, hospital admissions and deaths, compared with the current on-schedule, two-dose regimen.
Using a simulation model based on a sample population of 100,000 US adults, they ran scenarios to forecast potentially infectious interactions under different conditions over a six months.
It included varying levels of vaccine efficacy and administration rates, as well as varying assumptions as to whether the vaccine prevents transmission and serious symptoms or only prevents serious symptoms, including death.
They also examined the effect of delaying second doses for those younger than 65, but not before fully vaccinating older people.
The results suggest that under specific conditions, a decrease in cumulative mortality, infections and hospital admissions can be achieved when the second vaccine dose is delayed.
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Skewed figures
In the village of Mevagissey in southwest England the housing stock has doubled in the last century while the number of residents is half the historic high. The village's Neighbourhood Development Plan states that 26% of homes are holiday retreats. Prices are high, averaging around £300,000, £50,000 more than the Cornish average of £250,000. The local average wage is £15,458.
Key recommendations
- Fewer criminals put behind bars and more to serve sentences in the community, with short sentences scrapped and many inmates released earlier.
- Greater use of curfews and exclusion zones to deliver tougher supervision than ever on criminals.
- Explore wider powers for judges to punish offenders by blocking them from attending football matches, banning them from driving or travelling abroad through an expansion of ‘ancillary orders’.
- More Intensive Supervision Courts to tackle the root causes of crime such as alcohol and drug abuse – forcing repeat offenders to take part in tough treatment programmes or face prison.
Red flags
- Promises of high, fixed or 'guaranteed' returns.
- Unregulated structured products or complex investments often used to bypass traditional safeguards.
- Lack of clear information, vague language, no access to audited financials.
- Overseas companies targeting investors in other jurisdictions - this can make legal recovery difficult.
- Hard-selling tactics - creating urgency, offering 'exclusive' deals.
Courtesy: Carol Glynn, founder of Conscious Finance Coaching
Our Time Has Come
Alyssa Ayres, Oxford University Press
RESULTS
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Winner: Baccarat, William Buick (jockey), Charlie Appleby (trainer)
7.05pm: Handicap (78-94) $60,000 1,800m
Winner: Baroot, Christophe Soumillon, Mike de Kock
7.40pm: Firebreak Stakes Group 3 $200,000 1,600m
Winner: Heavy Metal, Mickael Barzalona, Salem bin Ghadayer
8.15pm: Handicap (95-108) $125,000 1,200m
Winner: Yalta, Mickael Barzalona, Salem bin Ghadayer
8.50pm: Balanchine Group 2 $200,000 1,800m
Winner: Promising Run, Pat Cosgrave, Saeed bin Suroor
9.25pm: Handicap (95-105) $125,000 1,800m
Winner: Blair House, James Doyle, Charlie Appleby
10pm: Handicap (95-105) $125,000 1,400m
Winner: Oh This Is Us, Tom Marquand, Richard Hannon
THE BIO
Bio Box
Role Model: Sheikh Zayed, God bless his soul
Favorite book: Zayed Biography of the leader
Favorite quote: To be or not to be, that is the question, from William Shakespeare's Hamlet
Favorite food: seafood
Favorite place to travel: Lebanon
Favorite movie: Braveheart
The burning issue
The internal combustion engine is facing a watershed moment – major manufacturer Volvo is to stop producing petroleum-powered vehicles by 2021 and countries in Europe, including the UK, have vowed to ban their sale before 2040. The National takes a look at the story of one of the most successful technologies of the last 100 years and how it has impacted life in the UAE.
Read part four: an affection for classic cars lives on
Read part three: the age of the electric vehicle begins
Read part one: how cars came to the UAE
The years Ramadan fell in May
Roll%20of%20Honour%2C%20men%E2%80%99s%20domestic%20rugby%20season
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KILLING OF QASSEM SULEIMANI
Zayed Sustainability Prize
AI traffic lights to ease congestion at seven points to Sheikh Zayed bin Sultan Street
The seven points are:
Shakhbout bin Sultan Street
Dhafeer Street
Hadbat Al Ghubainah Street (outbound)
Salama bint Butti Street
Al Dhafra Street
Rabdan Street
Umm Yifina Street exit (inbound)
HIJRA
Starring: Lamar Faden, Khairiah Nathmy, Nawaf Al-Dhufairy
Director: Shahad Ameen
Rating: 3/5
GAC GS8 Specs
Engine: 2.0-litre 4cyl turbo
Power: 248hp at 5,200rpm
Torque: 400Nm at 1,750-4,000rpm
Transmission: 8-speed auto
Fuel consumption: 9.1L/100km
On sale: Now
Price: From Dh149,900
The National's picks
4.35pm: Tilal Al Khalediah
5.10pm: Continous
5.45pm: Raging Torrent
6.20pm: West Acre
7pm: Flood Zone
7.40pm: Straight No Chaser
8.15pm: Romantic Warrior
8.50pm: Calandogan
9.30pm: Forever Young
UAE currency: the story behind the money in your pockets
BMW M5 specs
Engine: 4.4-litre twin-turbo V-8 petrol enging with additional electric motor
Power: 727hp
Torque: 1,000Nm
Transmission: 8-speed auto
Fuel consumption: 10.6L/100km
On sale: Now
Price: From Dh650,000
