Kawasaki disease, a rare autoimmune illness that mostly affects young children, was in the news recently in two different stories. In the first case, the disease was linked with Jett Travolta, son of the actor John Travolta. Jett died on Jan 2 after he had a seizure. He had apparently been ill for some time and his parents said he had Kawasaki disease.
It brought the condition to the attention of the public, and was followed by news of research in Australia into how the disease behaves.
Prof David Burgner from the University of Western Australia co-led a team that studied the entire human genome in an attempt to find new genes involved in making some children more susceptible to the disease.
It was first described by Dr Tomisaku Kawasaki in 1967, and although the condition is treatable, little has been learnt since about its causes.
It presents itself as an inflammatory condition. It affects several organs including the mucus membranes, the walls of blood vessels and lymph nodes. Its many symptoms include fever, rashes, swollen feet and hands, conjunctivitis and swollen lymph nodes. Children aged six months to five years seem particularly susceptible. It can be fatal, but only one in 1,000 cases result in death. Although it is rare, Prof Burgner explained why it was important to tackle the illness.
"Kawasaki disease is an important and serious illness of preschool children," he said. "Importantly it is the only childhood illness that damages the coronary arteries, in one quarter of untreated children and five to 10 per cent of treated children. This coronary damage may have long-term health implications, including death, angina and heart attacks in childhood and the need for coronary bypass surgery and even, rarely, heart transplant in childhood."
In the research study Prof Burgner's team considered genetic variation among 900 cases of the disease found in children from the US, Singapore, the Netherlands, the UK and Australia. The findings identified genes that may increase the susceptibility of some children to the disease, but further research is needed.
"Kawasaki disease is thought to be an abnormal immunological reaction to an unknown infectious trigger. There is a strong genetic component, so genes are important in determining susceptibility, as we believe all children are likely to be exposed to the trigger," Prof Burgner said.
"Our study is the first published that has investigated the entire human genome looking for important associated genes; most studies focus on a few candidate genes. We have identified at least eight new genes that have not previously been described in Kawasaki disease and some of them seem to function together. Some of the genes are involved in cardiovascular health - the function of blood vessels and in control of the immune system."
Identifying eight genes expands the scope of future research considerably. However, studying the entire human genome is not the biggest problem facing the researchers.
"The main issue is recruiting enough cases of Kawasaki disease, which is why we embarked on an international study. Ideally we need up to 5,000 cases to cover more of the human genome and find more of the important genes. We were very lucky to work with the Genome Institute of Singapore, who are one of the top genomics facilities in the world - this made the actual genetic laboratory work and analysis possible."
Dr Brian McCrindle, a cardiologist from the Hospital for Sick Children in Toronto, Canada, gave a talk on Kawasaki disease at the Arab Health Congress in Dubai in January. He believes the new findings offer potential for future research.
"The research is very preliminary and needs to be verified in other people's work, but there are some promising leads," he said. "Kawasaki disease can look like other diseases and sometimes it doesn't have typical presentation," he said.
Raising awareness is vital because the disease can be misdiagnosed, but developing a cure for any rare disease is difficult. However, Prof Burgner believes the identification of eight new genes will help with the treatment process.
"We hope that our work will contribute to the development of a diagnostic test and better treatment within the next few years, but we are not there yet," he said.
"At the moment doctors make a clinical diagnosis, based on the rash, fever et cetera, and there is no blood test that really helps. We urgently need a diagnostic test so children are treated earlier and Kawasaki disease is not missed, so reducing the long-term heart problems."
Finding a cure remains a possibility, though. "In Japan, for example, where one in 150 children suffer KD, it may be realistic to develop a vaccine, especially if Kawasaki disease increases the risk of atherosclerosis in later life - this is an unknown area at present," Prof Burgner said.
He also believes that the method used in his research of analysing the entire human genome will be adopted as the way forward in studying other infectious diseases.
"Genes are known to be important in determining susceptibility to infection so it is a proven and exciting method to try and identify the important genes that make people more or less likely to get infection and once they have it, more or less likely to survive. This should lead to better prevention and treatment. I suspect tuberculosis, HIV, hepatitis B and C and malaria will be the likely diseases that we will see these sorts of studies in very soon," he said.
For the moment, however, Prof Burgner is keen to continue to develop the research path he is pursuing with Kawasaki disease. There is also the possibility of collaborating with medical professionals in the Middle East.
"We are expanding the collaborative genetics group to include Asian and other populations, aiming to work together as a scientific community to crack this mysterious disease. We would very much like to hear from anyone in your region who has an interest in Kawasaki disease and sees many patients," he said.
Peter Donnelly is a science correspondent for the life science division at IIR Middle East
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COMPANY PROFILE
Name: N2 Technology
Founded: 2018
Based: Dubai, UAE
Sector: Startups
Size: 14
Funding: $1.7m from HNIs
The smuggler
Eldarir had arrived at JFK in January 2020 with three suitcases, containing goods he valued at $300, when he was directed to a search area.
Officers found 41 gold artefacts among the bags, including amulets from a funerary set which prepared the deceased for the afterlife.
Also found was a cartouche of a Ptolemaic king on a relief that was originally part of a royal building or temple.
The largest single group of items found in Eldarir’s cases were 400 shabtis, or figurines.
Khouli conviction
Khouli smuggled items into the US by making false declarations to customs about the country of origin and value of the items.
According to Immigration and Customs Enforcement, he provided “false provenances which stated that [two] Egyptian antiquities were part of a collection assembled by Khouli's father in Israel in the 1960s” when in fact “Khouli acquired the Egyptian antiquities from other dealers”.
He was sentenced to one year of probation, six months of home confinement and 200 hours of community service in 2012 after admitting buying and smuggling Egyptian antiquities, including coffins, funerary boats and limestone figures.
For sale
A number of other items said to come from the collection of Ezeldeen Taha Eldarir are currently or recently for sale.
Their provenance is described in near identical terms as the British Museum shabti: bought from Salahaddin Sirmali, "authenticated and appraised" by Hossen Rashed, then imported to the US in 1948.
- An Egyptian Mummy mask dating from 700BC-30BC, is on offer for £11,807 ($15,275) online by a seller in Mexico
- A coffin lid dating back to 664BC-332BC was offered for sale by a Colorado-based art dealer, with a starting price of $65,000
- A shabti that was on sale through a Chicago-based coin dealer, dating from 1567BC-1085BC, is up for $1,950
Mercer, the investment consulting arm of US services company Marsh & McLennan, expects its wealth division to at least double its assets under management (AUM) in the Middle East as wealth in the region continues to grow despite economic headwinds, a company official said.
Mercer Wealth, which globally has $160 billion in AUM, plans to boost its AUM in the region to $2-$3bn in the next 2-3 years from the present $1bn, said Yasir AbuShaban, a Dubai-based principal with Mercer Wealth.
“Within the next two to three years, we are looking at reaching $2 to $3 billion as a conservative estimate and we do see an opportunity to do so,” said Mr AbuShaban.
Mercer does not directly make investments, but allocates clients’ money they have discretion to, to professional asset managers. They also provide advice to clients.
“We have buying power. We can negotiate on their (client’s) behalf with asset managers to provide them lower fees than they otherwise would have to get on their own,” he added.
Mercer Wealth’s clients include sovereign wealth funds, family offices, and insurance companies among others.
From its office in Dubai, Mercer also looks after Africa, India and Turkey, where they also see opportunity for growth.
Wealth creation in Middle East and Africa (MEA) grew 8.5 per cent to $8.1 trillion last year from $7.5tn in 2015, higher than last year’s global average of 6 per cent and the second-highest growth in a region after Asia-Pacific which grew 9.9 per cent, according to consultancy Boston Consulting Group (BCG). In the region, where wealth grew just 1.9 per cent in 2015 compared with 2014, a pickup in oil prices has helped in wealth generation.
BCG is forecasting MEA wealth will rise to $12tn by 2021, growing at an annual average of 8 per cent.
Drivers of wealth generation in the region will be split evenly between new wealth creation and growth of performance of existing assets, according to BCG.
Another general trend in the region is clients’ looking for a comprehensive approach to investing, according to Mr AbuShaban.
“Institutional investors or some of the families are seeing a slowdown in the available capital they have to invest and in that sense they are looking at optimizing the way they manage their portfolios and making sure they are not investing haphazardly and different parts of their investment are working together,” said Mr AbuShaban.
Some clients also have a higher appetite for risk, given the low interest-rate environment that does not provide enough yield for some institutional investors. These clients are keen to invest in illiquid assets, such as private equity and infrastructure.
“What we have seen is a desire for higher returns in what has been a low-return environment specifically in various fixed income or bonds,” he said.
“In this environment, we have seen a de facto increase in the risk that clients are taking in things like illiquid investments, private equity investments, infrastructure and private debt, those kind of investments were higher illiquidity results in incrementally higher returns.”
The Abu Dhabi Investment Authority, one of the largest sovereign wealth funds, said in its 2016 report that has gradually increased its exposure in direct private equity and private credit transactions, mainly in Asian markets and especially in China and India. The authority’s private equity department focused on structured equities owing to “their defensive characteristics.”
Asia%20Cup%202022
%3Cp%3E%3Cstrong%3EWhat%3C%2Fstrong%3E%3Cbr%3EAsia%20Cup%20final%3A%20Sri%20Lanka%20v%20Pakistan%3Cbr%3E%3Cbr%3E%3Cstrong%3EWhen%20%3C%2Fstrong%3E%3Cbr%3ESunday%2C%20September%2011%2C%20from%206pm%3Cbr%3E%3Cbr%3E%3Cstrong%3EWhere%3C%2Fstrong%3E%3Cbr%3EDubai%20International%20Stadium%3Cbr%3E%3Cbr%3E%3Cstrong%3EHow%20to%20watch%3C%2Fstrong%3E%3Cbr%3ECatch%20the%20live%20action%20on%20Starzplay%20across%20Mena%20region.%26nbsp%3B%3C%2Fp%3E%0A
Volvo ES90 Specs
Engine: Electric single motor (96kW), twin motor (106kW) and twin motor performance (106kW)
Power: 333hp, 449hp, 680hp
Torque: 480Nm, 670Nm, 870Nm
On sale: Later in 2025 or early 2026, depending on region
Price: Exact regional pricing TBA
Specs
Engine: Duel electric motors
Power: 659hp
Torque: 1075Nm
On sale: Available for pre-order now
Price: On request
England World Cup squad
Eoin Morgan (capt), Moeen Ali, Jofra Archer, Jonny Bairstow, Jos Buttler (wkt), Tom Curran, Liam Dawson, Liam Plunkett, Adil Rashid, Joe Root, Jason Roy, Ben Stokes, James Vince, Chris Woakes, Mark Wood
Specs
Engine: Electric motor generating 54.2kWh (Cooper SE and Aceman SE), 64.6kW (Countryman All4 SE)
Power: 218hp (Cooper and Aceman), 313hp (Countryman)
Torque: 330Nm (Cooper and Aceman), 494Nm (Countryman)
On sale: Now
Price: From Dh158,000 (Cooper), Dh168,000 (Aceman), Dh190,000 (Countryman)
The White Lotus: Season three
Creator: Mike White
Starring: Walton Goggins, Jason Isaacs, Natasha Rothwell
Rating: 4.5/5
The%20pillars%20of%20the%20Dubai%20Metaverse%20Strategy
%3Cp%3EEncourage%20innovation%20in%20the%20metaverse%20field%20and%20boost%20economic%20contribution%3C%2Fp%3E%0A%3Cp%3EDevelop%20outstanding%20talents%20through%20education%20and%20training%3C%2Fp%3E%0A%3Cp%3EDevelop%20applications%20and%20the%20way%20they%20are%20used%20in%20Dubai's%20government%20institutions%3C%2Fp%3E%0A%3Cp%3EAdopt%2C%20expand%20and%20promote%20secure%20platforms%20globally%3C%2Fp%3E%0A%3Cp%3EDevelop%20the%20infrastructure%20and%20regulations%3C%2Fp%3E%0A
A MINECRAFT MOVIE
Director: Jared Hess
Starring: Jack Black, Jennifer Coolidge, Jason Momoa
Rating: 3/5
The%20trailblazers
%3Cp%3ESixteen%20boys%20and%2015%20girls%20have%20gone%20on%20from%20Go-Pro%20Academy%20in%20Dubai%20to%20either%20professional%20contracts%20abroad%20or%20scholarships%20in%20the%20United%20States.%20Here%20are%20two%20of%20the%20most%20prominent.%0D%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EGeorgia%20Gibson%20(Newcastle%20United)%3C%2Fstrong%3E%0D%3Cbr%3EThe%20reason%20the%20academy%20in%20Dubai%20first%20set%20up%20a%20girls%E2%80%99%20programme%20was%20to%20help%20Gibson%20reach%20her%20potential.%20Now%20she%20plays%20professionally%20for%20Newcastle%20United%20in%20the%20UK.%0D%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EMackenzie%20Hunt%20(Everton)%3C%2Fstrong%3E%0D%3Cbr%3EAttended%20DESS%20in%20Dubai%2C%20before%20heading%20to%20the%20UK%20to%20join%20Everton%20full%20time%20as%20a%20teenager.%20He%20was%20on%20the%20bench%20for%20the%20first%20team%20as%20recently%20as%20their%20fixture%20against%20Brighton%20on%20February%2024.%0D%3C%2Fp%3E%0A
The Abu Dhabi Awards explained:
What are the awards? They honour anyone who has made a contribution to life in Abu Dhabi.
Are they open to only Emiratis? The awards are open to anyone, regardless of age or nationality, living anywhere in the world.
When do nominations close? The process concludes on December 31.
How do I nominate someone? Through the website.
When is the ceremony? The awards event will take place early next year.
The specs
Engine: 3.0-litre six-cylinder turbo
Power: 398hp from 5,250rpm
Torque: 580Nm at 1,900-4,800rpm
Transmission: Eight-speed auto
Fuel economy, combined: 6.5L/100km
On sale: December
Price: From Dh330,000 (estimate)
ULTRA PROCESSED FOODS
- Carbonated drinks, sweet or savoury packaged snacks, confectionery, mass-produced packaged breads and buns
- margarines and spreads; cookies, biscuits, pastries, cakes, and cake mixes, breakfast cereals, cereal and energy bars;
- energy drinks, milk drinks, fruit yoghurts and fruit drinks, cocoa drinks, meat and chicken extracts and instant sauces
- infant formulas and follow-on milks, health and slimming products such as powdered or fortified meal and dish substitutes,
- many ready-to-heat products including pre-prepared pies and pasta and pizza dishes, poultry and fish nuggets and sticks, sausages, burgers, hot dogs, and other reconstituted meat products, powdered and packaged instant soups, noodles and desserts.
UAE currency: the story behind the money in your pockets
