Hope Consortium: UK looks to inactivated Valneva vaccine to tackle Covid-19 variants


Gillian Duncan
  • English
  • Arabic

The UK could pin its hopes on a new inactivated vaccine to help guard against variants of the coronavirus.

Nadhim Zahawi, the UK’s vaccine minister, said Valneva's shot could provide more varied protection against new strains.

French drug maker Valneva has the vaccine in development at its lab in Scotland. It expects results from its Phase I and II trials within weeks.

Speaking at the World Immunisation & Logistics Summit, a virtual event organised by the Hope Consortium in Abu Dhabi, Mr Zahawi said the country was working on “future proofing” its successful vaccination campaign, which has seen more than 30 million people receive their first shot.

We are future-proofing by working on the possibility of an autumn jab, a booster jab. And then probably an annual vaccination

Two vaccines will be important in what happens next, he said.

“We have announced a very important collaboration with CureVac, which is another messenger RNA technology company that will be manufactured in the UK at scale,” he said.

“And then we have the Valneva vaccine, which is from a French company and [is] being manufactured in Scotland for the end of the year, which will probably form our annual vaccination programme.

“It’s a whole inactivated virus vaccine, which the scientists have great hope for in terms of dealing with any variants.

“So we are looking to future-proof our vaccination programme against any virus variants that may emerge and share it with the world. So we have put 548 million through Covax,” he added.

Mr Zahawi said his government was working with drug makers "on the possibility of an autumn jab, a booster jab. Certainly for the most vulnerable communities. And then probably an annual vaccination".

Boris Johnson watches a technician work at Valneva's vaccine lab in Livingston, Scotland. Wattie Cheung AFP
Boris Johnson watches a technician work at Valneva's vaccine lab in Livingston, Scotland. Wattie Cheung AFP

Vaccine 'suitable for children'

The British government has already pre-purchased 60 million doses from Valneva for this year alone.

Prime Minister Boris Johnson visited the company's lab in Livingston, Scotland, when commercial production began last month.

It is produced using a dead version of the virus, like Sinopharm, the most widely available vaccine in the UAE.

The vaccine is unlikely to be approved until the end of 2021, but it is seen as an ideal annual booster shot.

Valvena has suggested it may be suitable for children.

Some experts believe inactivated vaccines may be more effective against new mutations because they are made using the whole virus, offering protection against multiple areas.

The majority of the current crop of vaccines are designed to generate antibodies against the spike only, which the Sars-CoV-2 virus uses to enter cells.

Many of the most concerning mutations to have emerged in the virus in recent months have appeared in the spike, which has rendered the vaccines less effective.

Initial tests using antibodies produced by the Pfizer vaccine showed the South African variant did not substantially affect its efficacy.

But a more recent study predicted greater problems, finding the strain was "markedly more resistant" to the Pfizer and Moderna vaccines, with a 10 to 12-fold reduction in neutralising antibodies.

By contrast, tests using antibodies generated against the Sinopharm vaccine showed they were still able to neutralise the variant, although the effect was slightly weaker than against the original virus.

The reduction in antibodies using the blood of someone vaccinated with the Sinopharm shot were around 1.6 fold less effective against the South African variant, according to the early research. The neutralisation of the virus was "largely preserved," it said.

The UK is currently using Pfizer-BioNTech and Oxford-AstraZeneca vaccine; the latter was found to offer just 10 per cent protection against developing mild to moderate symptoms from the South African variant.

The years Ramadan fell in May

1987

1954

1921

1888

FINAL SCORES

Fujairah 130 for 8 in 20 overs

(Sandy Sandeep 29, Hamdan Tahir 26 no, Umair Ali 2-15)

Sharjah 131 for 8 in 19.3 overs

(Kashif Daud 51, Umair Ali 20, Rohan Mustafa 2-17, Sabir Rao 2-26)

The specs

Price, base / as tested Dh960,000
Engine 3.9L twin-turbo V8 
Transmission Seven-speed dual-clutch automatic
Power 661hp @8,000rpm
Torque 760Nm @ 3,000rpm
Fuel economy, combined 11.4L / 100k

The burning issue

The internal combustion engine is facing a watershed moment – major manufacturer Volvo is to stop producing petroleum-powered vehicles by 2021 and countries in Europe, including the UK, have vowed to ban their sale before 2040. The National takes a look at the story of one of the most successful technologies of the last 100 years and how it has impacted life in the UAE.

Read part three: the age of the electric vehicle begins

Read part two: how climate change drove the race for an alternative 

Read part one: how cars came to the UAE

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%3Cp%3E%3Cstrong%3EEngine%3A%20%3C%2Fstrong%3E2.0-litre%204cyl%20turbo%0D%3Cbr%3E%3Cstrong%3EPower%3A%20%3C%2Fstrong%3E261hp%20at%205%2C500rpm%0D%3Cbr%3E%3Cstrong%3ETorque%3A%20%3C%2Fstrong%3E400Nm%20at%201%2C750-4%2C000rpm%0D%3Cbr%3E%3Cstrong%3ETransmission%3A%20%3C%2Fstrong%3E7-speed%20dual-clutch%20auto%0D%3Cbr%3E%3Cstrong%3EFuel%20consumption%3A%20%3C%2Fstrong%3E10.5L%2F100km%0D%3Cbr%3E%3Cstrong%3EOn%20sale%3A%20%3C%2Fstrong%3ENow%0D%3Cbr%3E%3Cstrong%3EPrice%3A%20%3C%2Fstrong%3EFrom%20Dh129%2C999%20(VX%20Luxury)%3B%20from%20Dh149%2C999%20(VX%20Black%20Gold)%3C%2Fp%3E%0A
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The specs

Engine: 1.5-litre turbo

Power: 181hp

Torque: 230Nm

Transmission: 6-speed automatic

Starting price: Dh79,000

On sale: Now

The specs

Price, base / as tested Dh1,100,000 (est)

Engine 5.2-litre V10

Gearbox seven-speed dual clutch

Power 630bhp @ 8,000rpm

Torque 600Nm @ 6,500rpm

Fuel economy, combined 15.7L / 100km (est) 

The Facility’s Versatility

Between the start of the 2020 IPL on September 20, and the end of the Pakistan Super League this coming Thursday, the Zayed Cricket Stadium has had an unprecedented amount of traffic.
Never before has a ground in this country – or perhaps anywhere in the world – had such a volume of major-match cricket.
And yet scoring has remained high, and Abu Dhabi has seen some classic encounters in every format of the game.
 
October 18, IPL, Kolkata Knight Riders tied with Sunrisers Hyderabad
The two playoff-chasing sides put on 163 apiece, before Kolkata went on to win the Super Over
 
January 8, ODI, UAE beat Ireland by six wickets
A century by CP Rizwan underpinned one of UAE’s greatest ever wins, as they chased 270 to win with an over to spare
 
February 6, T10, Northern Warriors beat Delhi Bulls by eight wickets
The final of the T10 was chiefly memorable for a ferocious over of fast bowling from Fidel Edwards to Nicholas Pooran
 
March 14, Test, Afghanistan beat Zimbabwe by six wickets
Eleven wickets for Rashid Khan, 1,305 runs scored in five days, and a last session finish
 
June 17, PSL, Islamabad United beat Peshawar Zalmi by 15 runs
Usman Khawaja scored a hundred as Islamabad posted the highest score ever by a Pakistan team in T20 cricket

In-demand jobs and monthly salaries
  • Technology expert in robotics and automation: Dh20,000 to Dh40,000 
  • Energy engineer: Dh25,000 to Dh30,000 
  • Production engineer: Dh30,000 to Dh40,000 
  • Data-driven supply chain management professional: Dh30,000 to Dh50,000 
  • HR leader: Dh40,000 to Dh60,000 
  • Engineering leader: Dh30,000 to Dh55,000 
  • Project manager: Dh55,000 to Dh65,000 
  • Senior reservoir engineer: Dh40,000 to Dh55,000 
  • Senior drilling engineer: Dh38,000 to Dh46,000 
  • Senior process engineer: Dh28,000 to Dh38,000 
  • Senior maintenance engineer: Dh22,000 to Dh34,000 
  • Field engineer: Dh6,500 to Dh7,500
  • Field supervisor: Dh9,000 to Dh12,000
  • Field operator: Dh5,000 to Dh7,000
Know before you go
  • Jebel Akhdar is a two-hour drive from Muscat airport or a six-hour drive from Dubai. It’s impossible to visit by car unless you have a 4x4. Phone ahead to the hotel to arrange a transfer.
  • If you’re driving, make sure your insurance covers Oman.
  • By air: Budget airlines Air Arabia, Flydubai and SalamAir offer direct routes to Muscat from the UAE.
  • Tourists from the Emirates (UAE nationals not included) must apply for an Omani visa online before arrival at evisa.rop.gov.om. The process typically takes several days.
  • Flash floods are probable due to the terrain and a lack of drainage. Always check the weather before venturing into any canyons or other remote areas and identify a plan of escape that includes high ground, shelter and parking where your car won’t be overtaken by sudden downpours.

 

The years Ramadan fell in May

1987

1954

1921

1888

The biog

Name: Abeer Al Shahi

Emirate: Sharjah – Khor Fakkan

Education: Master’s degree in special education, preparing for a PhD in philosophy.

Favourite activities: Bungee jumping

Favourite quote: “My people and I will not settle for anything less than first place” – Sheikh Mohammed bin Rashid.

The burning issue

The internal combustion engine is facing a watershed moment – major manufacturer Volvo is to stop producing petroleum-powered vehicles by 2021 and countries in Europe, including the UK, have vowed to ban their sale before 2040. The National takes a look at the story of one of the most successful technologies of the last 100 years and how it has impacted life in the UAE. 

Read part four: an affection for classic cars lives on

Read part three: the age of the electric vehicle begins

Read part two: how climate change drove the race for an alternative 

The five pillars of Islam

1. Fasting

2. Prayer

3. Hajj

4. Shahada

5. Zakat