A fast-acting ketamine-based nasal spray could offer hope to thousands of people with depression in the UAE when it is introduced in March.
Esketamine is described by doctors as a "fast-acting" medicine that must be used in a controlled environment due to its psychoactive properties.
Although the treatment will offer another weapon for doctors against depression, psychiatrists are divided on how effective it may be.
With more people seeking help as mental health stigma fades, psychiatrists hope the Spravato treatment will throw a lifeline to those who have experienced little improvement from established drugs like Prozac.
Unlike conventional antidepressants which can take three to four weeks to show improvement in depressive symptoms, this drug can produce positive changes within hours
Other medics have said the drug could lead to addiction and abuse, though it is expected to be strictly controlled.
Ketamine's status as a party drug often referred to as "horse transquiliser" has caused reticence and confusion about the treatment.
"The reservations have included a potential for abuse and dependence, as well as the cost factor," said Dr Saeed Islam, a consultant psychiatrist and medical director at Priory's Middle East clinic.
"Unlike conventional antidepressants which can take three to four weeks to show improvement in depressive symptoms, this drug can produce positive changes within hours.
“The cost is still an issue and it will remain a treatment option for a few patients only.”
Other risks listed on medical licensing documents include a chance of transient perception disorders, disturbances in consciousness, cystitis and increases in blood pressure.
A group of 12 psychiatrists in the UK expressed their reservations to regulators, claiming short-term improvements similar to recreational drugs should not have been used as a basis to approve the medication as a treatment for depression.
Doctors described the drug as a "breakthrough" when it was announced that Spravato would be made available in the UAE earlier this year.
While traditional antidepressants work by boosting serotonin – a neurotransmitter thought to have a good influence on mood, emotion and sleep – in the brain, Spravato is the first drug in decades to target a new brain pathway: glutamate.
Glutamate is a neurotransmitter that plays an important role in learning and memory and is considered essential for normal brain function.
But treatment will not be cheap and is expected to be priced at about $600 (Dh2,200) per session.
In the United States and Europe, the drug costs between Dh17,000 and Dh25,000 in the first month, reducing to Dh8,700 to Dh13,000 monthly. Medication would be free for Emiratis and some other insurance plan holders.
It is produced by Johnson & Johnson’s Janssen Pharmaceuticals and won approval by US drug watchdog the Food and Drug Administration in March.
The UK's National Institute for Health and Care Excellence is expected to decide if esketamine will be made available on the NHS in early 2020.
It is also recommended by a European Medicines Agency panel based on a series of long-term trials on patients who had not responded to conventional drugs.
When given esketamine, researchers found patients had a 51 per cent lower risk of relapse than those given oral antidepressants and a placebo nasal spray.
Esketamine is expected to be available at Abu Dhabi's Sheikh Khalifa Medical City from March.
“We are very much aware of this drug since its FDA approval and its potential benefits to patients,” said Dr Padmaraju Varry, a psychiatrist at NMC Hospitals.
Dr Varrey treats about 20 patients a week with depression, but not all are suited to existing drugs, he said.
“Depression is a common issue here in the UAE, like any other country,” said Dr Varrey.
“The stigma is moving away as people become more understanding of the symptoms because of positive media and information campaigns.
“People now appreciate it is a recognised medical condition and there is effective treatment out there.
“Relaxing this stigma means we are seeing more patients who are now prepared to come forward for treatment and accept they have a problem.
“We are looking forward to the availability of this medicine to help more patients in Abu Dhabi.”
UAE currency: the story behind the money in your pockets
Sole survivors
- Cecelia Crocker was on board Northwest Airlines Flight 255 in 1987 when it crashed in Detroit, killing 154 people, including her parents and brother. The plane had hit a light pole on take off
- George Lamson Jr, from Minnesota, was on a Galaxy Airlines flight that crashed in Reno in 1985, killing 68 people. His entire seat was launched out of the plane
- Bahia Bakari, then 12, survived when a Yemenia Airways flight crashed near the Comoros in 2009, killing 152. She was found clinging to wreckage after floating in the ocean for 13 hours.
- Jim Polehinke was the co-pilot and sole survivor of a 2006 Comair flight that crashed in Lexington, Kentucky, killing 49.
TECH%20SPECS%3A%20APPLE%20WATCH%20SE%20(second%20generation)
%3Cp%3EDisplay%3A%2040mm%2C%20324%20x%20394%3B%2044mm%2C%20368%20x%20448%3B%20Retina%20LTPO%20OLED%2C%20up%20to%201000%20nits%3B%20Ion-X%20glass%3C%2Fp%3E%0A%3Cp%3EProcessor%3A%20Apple%20S8%2C%20W3%20wireless%3C%2Fp%3E%0A%3Cp%3ECapacity%3A%2032GB%3C%2Fp%3E%0A%3Cp%3EMemory%3A%201GB%3C%2Fp%3E%0A%3Cp%3EPlatform%3A%20watchOS%209%3C%2Fp%3E%0A%3Cp%3EHealth%20metrics%3A%202nd-gen%20heart%20rate%20sensor%2C%20workouts%2C%20fall%2Fcrash%20detection%3B%20emergency%20SOS%2C%20international%20emergency%20calling%3C%2Fp%3E%0A%3Cp%3EConnectivity%3A%20GPS%2FGPS%20%2B%20cellular%3B%20Wi-Fi%2C%20LTE%2C%20Bluetooth%205.3%2C%20NFC%20(Apple%20Pay)%3C%2Fp%3E%0A%3Cp%3EDurability%3A%20Water%20resistant%20up%20to%2050m%3C%2Fp%3E%0A%3Cp%3EBattery%3A%20269mAh%20Li-ion%2C%20up%20to%2018h%2C%20wireless%20charging%3C%2Fp%3E%0A%3Cp%3ECards%3A%20eSIM%3C%2Fp%3E%0A%3Cp%3EFinishes%3A%20Aluminium%3B%20midnight%2C%20silver%2C%20starlight%3C%2Fp%3E%0A%3Cp%3EIn%20the%20box%3A%20Watch%20SE%2C%20magnetic-to-USB-C%20charging%20cable%2C%20band%2Floop%3C%2Fp%3E%0A%3Cp%3EPrice%3A%20Starts%20at%20Dh999%20(40mm)%20%2F%201%2C119%20(44mm)%3C%2Fp%3E%0A
The Africa Institute 101
Housed on the same site as the original Africa Hall, which first hosted an Arab-African Symposium in 1976, the newly renovated building will be home to a think tank and postgraduate studies hub (it will offer master’s and PhD programmes). The centre will focus on both the historical and contemporary links between Africa and the Gulf, and will serve as a meeting place for conferences, symposia, lectures, film screenings, plays, musical performances and more. In fact, today it is hosting a symposium – 5-plus-1: Rethinking Abstraction that will look at the six decades of Frank Bowling’s career, as well as those of his contemporaries that invested social, cultural and personal meaning into abstraction.
Our family matters legal consultant
Name: Hassan Mohsen Elhais
Position: legal consultant with Al Rowaad Advocates and Legal Consultants.
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%3Cp%3E%3Cstrong%3EDeveloper%3A%3C%2Fstrong%3E%20Sucker%20Punch%20Productions%3Cbr%3E%3Cstrong%3EPublisher%3A%3C%2Fstrong%3E%20Sony%20Computer%20Entertainment%3Cbr%3E%3Cstrong%3EConsole%3A%3C%2Fstrong%3E%20PlayStation%202%20to%205%3Cbr%3E%3Cstrong%3ERating%3A%3C%2Fstrong%3E%205%2F5%3C%2Fp%3E%0A
Global state-owned investor ranking by size
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United States
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China
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UAE
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Japan
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Norway
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Canada
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Singapore
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Australia
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Saudi Arabia
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South Korea
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Honeymoonish
%3Cp%3E%3Cstrong%3EDirector%3A%3C%2Fstrong%3E%20Elie%20El%20Samaan%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EStarring%3A%20%3C%2Fstrong%3ENour%20Al%20Ghandour%2C%20Mahmoud%20Boushahri%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3ERating%3A%3C%2Fstrong%3E%203%2F5%3C%2Fp%3E%0A
Venom
Director: Ruben Fleischer
Cast: Tom Hardy, Michelle Williams, Riz Ahmed
Rating: 1.5/5
More from Rashmee Roshan Lall
Gothia Cup 2025
4,872 matches
1,942 teams
116 pitches
76 nations
26 UAE teams
15 Lebanese teams
2 Kuwaiti teams
Sleep Well Beast
The National
4AD
APPLE IPAD MINI (A17 PRO)
Display: 21cm Liquid Retina Display, 2266 x 1488, 326ppi, 500 nits
Chip: Apple A17 Pro, 6-core CPU, 5-core GPU, 16-core Neural Engine
Storage: 128/256/512GB
Main camera: 12MP wide, f/1.8, digital zoom up to 5x, Smart HDR 4
Front camera: 12MP ultra-wide, f/2.4, Smart HDR 4, full-HD @ 25/30/60fps
Biometrics: Touch ID, Face ID
Colours: Blue, purple, space grey, starlight
In the box: iPad mini, USB-C cable, 20W USB-C power adapter
Price: From Dh2,099
The bio:
Favourite holiday destination: I really enjoyed Sri Lanka and Vietnam but my dream destination is the Maldives.
Favourite food: My mum’s Chinese cooking.
Favourite film: Robocop, followed by The Terminator.
Hobbies: Off-roading, scuba diving, playing squash and going to the gym.
UAE%20SQUAD
%3Cp%3EMuhammad%20Waseem%20(captain)%2C%20Aayan%20Khan%2C%20Aryan%20Lakra%2C%20Ashwanth%20Valthapa%2C%20Asif%20Khan%2C%20Aryansh%20Sharma%2C%20CP%20Rizwaan%2C%20Hazrat%20Billal%2C%20Junaid%20Siddique%2C%20Karthik%20Meiyappan%2C%20Rohan%20Mustafa%2C%20Vriitya%20Aravind%2C%20Zahoor%20Khan%20and%20Zawar%20Farid.%3C%2Fp%3E%0A
Understand What Black Is
The Last Poets
(Studio Rockers)
Sholto Byrnes on Myanmar politics
<html><head><meta http-equiv="Content-Type" content="text/html" charset="UTF-8" /></head><body><!--PSTYLE=* Labels%3aFH Label 18 Sport--><p>Beach soccer</p><!--PSTYLE=BY Byline--><p>Amith Passela</p><p /></body></html>
Pharaoh's curse
British aristocrat Lord Carnarvon, who funded the expedition to find the Tutankhamun tomb, died in a Cairo hotel four months after the crypt was opened.
He had been in poor health for many years after a car crash, and a mosquito bite made worse by a shaving cut led to blood poisoning and pneumonia.
Reports at the time said Lord Carnarvon suffered from “pain as the inflammation affected the nasal passages and eyes”.
Decades later, scientists contended he had died of aspergillosis after inhaling spores of the fungus aspergillus in the tomb, which can lie dormant for months. The fact several others who entered were also found dead withiin a short time led to the myth of the curse.
UAE v Gibraltar
What: International friendly
When: 7pm kick off
Where: Rugby Park, Dubai Sports City
Admission: Free
Online: The match will be broadcast live on Dubai Exiles’ Facebook page
UAE squad: Lucas Waddington (Dubai Exiles), Gio Fourie (Exiles), Craig Nutt (Abu Dhabi Harlequins), Phil Brady (Harlequins), Daniel Perry (Dubai Hurricanes), Esekaia Dranibota (Harlequins), Matt Mills (Exiles), Jaen Botes (Exiles), Kristian Stinson (Exiles), Murray Reason (Abu Dhabi Saracens), Dave Knight (Hurricanes), Ross Samson (Jebel Ali Dragons), DuRandt Gerber (Exiles), Saki Naisau (Dragons), Andrew Powell (Hurricanes), Emosi Vacanau (Harlequins), Niko Volavola (Dragons), Matt Richards (Dragons), Luke Stevenson (Harlequins), Josh Ives (Dubai Sports City Eagles), Sean Stevens (Saracens), Thinus Steyn (Exiles)
MATCH INFO
AC Milan v Inter, Sunday, 6pm (UAE), match live on BeIN Sports
The specs
Engine: Four electric motors, one at each wheel
Power: 579hp
Torque: 859Nm
Transmission: Single-speed automatic
Price: From Dh825,900
On sale: Now
Key facilities
- Olympic-size swimming pool with a split bulkhead for multi-use configurations, including water polo and 50m/25m training lanes
- Premier League-standard football pitch
- 400m Olympic running track
- NBA-spec basketball court with auditorium
- 600-seat auditorium
- Spaces for historical and cultural exploration
- An elevated football field that doubles as a helipad
- Specialist robotics and science laboratories
- AR and VR-enabled learning centres
- Disruption Lab and Research Centre for developing entrepreneurial skills
Veere di Wedding
Dir: Shashanka Ghosh
Starring: Kareena Kapoo-Khan, Sonam Kapoor, Swara Bhaskar and Shikha Talsania
Verdict: 4 Stars
RESULT
Leeds United 1 Manchester City 1
Leeds: Rodrigo (59')
Man City: Sterling (17')
Man of the Match: Rodrigo Moreno (Leeds)
The specs: 2018 Audi RS5
Price, base: Dh359,200
Engine: 2.9L twin-turbo V6
Transmission: Eight-speed automatic
Power: 450hp at 5,700rpm
Torque: 600Nm at 1,900rpm
Fuel economy, combined: 8.7L / 100km
