DUBAI // Arabs suffer from one of the highest rates of genetic disease in the world, according to a research institute.
Some 906 genetic disorders have been identified in Arabs and their descendants, reports the Centre for Arab Genomic Studies (CAGS), and about 200 of those are prevalent among Arabs in the GCC alone.
It warns that the problem will require research and collaboration among medical communities.
In the UAE, 241 disorders have been identified in Arab citizens and expatriates combined, making the incidence in this country the second-highest in the Arab world after Oman; 119 genetic disorders are specific to Emiratis.
These figures are thought likely to rise, too, as researchers discover new disorders in the Arab world and record them in a database being developed by the CAGS.
The centre, funded by the Sheikh Hamdan Award for Medical Sciences, has completed studies of Bahrain, Oman and the UAE.
It plans to compile extensive data on genetic disorders in every Arab country to help pave the way for treatment and prevention-based health policies in the region.
Patients are defined as Arab if they are of Arab ancestry, whether on the maternal or paternal side and regardless of where they happen to live. Countries such as Brazil, Canada and France, for example, have large Arab communities.
"Why build this database? It gives us a bird's-eye view of each country on genetic diseases. Some are epidemic and some very rare," said Dr Ghazi Tadmouri, the assistant director of the CAGS.
Several common diseases in the UAE, Oman and Bahrain have reached epidemic levels - more than 100 cases per 100,000.
They include thalassaemia (a blood disorder), diabetes, breast cancer and Down's syndrome. Less common genetic disorders in the Emirates include muscular dystrophy and kidney disease.
About 63 per cent of the genetic conditions in Arab populations are due mostly to marriage between close relatives such as first cousins, clinically known as consanguinity.
Such marriages, deeply ingrained in Arab culture, are on the rise in the UAE, where the rate is the fifth-highest in the Arab world.
In Dubai, 40 per cent of marriages are between relatives, according to the latest statistics. In Al Ain that figure reaches 54 per cent, and in Abu Dhabi 32 per cent.
Across the Arab world, Sudan and Mauritania have the highest rates, amounting to two-thirds of all marriages. However, consanguinity is on the decline in, for example, Egypt and Tunisia.
The good news is that more than half the genetic disorders in Arab populations are the result of a defect in only one gene, which means it would be relatively easy to screen for such a gene and to prevent or treat the disorder.
However, Dr Tadmouri said there were no national projects aimed at controlling genetic disorders in most Arab countries.
Pre-natal detection of disease should be more available, he said, while early diagnosis was essential in treating many disorders. Other preventive measures included screening potential spouses for defective recessive genes.
"It is becoming mandatory to do basic screening for thalassaemia and other diseases before marriage," Dr Tadmouri said.
He called on medical professionals in Arab countries to keep track of genetic disorders. When he first started compiling data for the centre's database in 2004, he found there were many genetic disorders in the UAE that were not documented.
"There's little or no incentive for doctors here to keep track of such data from their patients," he said.
"We're hoping that the western educational establishments that are opening here will go beyond teaching a few disciplines here and there.
"We're hoping they will establish real academic institutions and build a vibrant academic atmosphere in the medical sciences.
"That's what the Arab world needs to overcome genetic disorders."
relass@thenational.ae
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THE BIO
Favourite book: ‘Purpose Driven Life’ by Rick Warren
Favourite travel destination: Switzerland
Hobbies: Travelling and following motivational speeches and speakers
Favourite place in UAE: Dubai Museum
Formula Middle East Calendar (Formula Regional and Formula 4)
Round 1: January 17-19, Yas Marina Circuit – Abu Dhabi
Round 2: January 22-23, Yas Marina Circuit – Abu Dhabi
Round 3: February 7-9, Dubai Autodrome – Dubai
Round 4: February 14-16, Yas Marina Circuit – Abu Dhabi
Round 5: February 25-27, Jeddah Corniche Circuit – Saudi Arabia
The White Lotus: Season three
Creator: Mike White
Starring: Walton Goggins, Jason Isaacs, Natasha Rothwell
Rating: 4.5/5
The specs
Engine: Four electric motors, one at each wheel
Power: 579hp
Torque: 859Nm
Transmission: Single-speed automatic
Price: From Dh825,900
On sale: Now
Breaking News: The Remaking of Journalism and Why It Matters Now
Alan Rushbridger, Canongate
Key facilities
- Olympic-size swimming pool with a split bulkhead for multi-use configurations, including water polo and 50m/25m training lanes
- Premier League-standard football pitch
- 400m Olympic running track
- NBA-spec basketball court with auditorium
- 600-seat auditorium
- Spaces for historical and cultural exploration
- An elevated football field that doubles as a helipad
- Specialist robotics and science laboratories
- AR and VR-enabled learning centres
- Disruption Lab and Research Centre for developing entrepreneurial skills
MATCH INFO
Europa League semi-final, second leg
Atletico Madrid (1) v Arsenal (1)
Where: Wanda Metropolitano
When: Thursday, May 3
Live: On BeIN Sports HD
Origin
Dan Brown
Doubleday
The smuggler
Eldarir had arrived at JFK in January 2020 with three suitcases, containing goods he valued at $300, when he was directed to a search area.
Officers found 41 gold artefacts among the bags, including amulets from a funerary set which prepared the deceased for the afterlife.
Also found was a cartouche of a Ptolemaic king on a relief that was originally part of a royal building or temple.
The largest single group of items found in Eldarir’s cases were 400 shabtis, or figurines.
Khouli conviction
Khouli smuggled items into the US by making false declarations to customs about the country of origin and value of the items.
According to Immigration and Customs Enforcement, he provided “false provenances which stated that [two] Egyptian antiquities were part of a collection assembled by Khouli's father in Israel in the 1960s” when in fact “Khouli acquired the Egyptian antiquities from other dealers”.
He was sentenced to one year of probation, six months of home confinement and 200 hours of community service in 2012 after admitting buying and smuggling Egyptian antiquities, including coffins, funerary boats and limestone figures.
For sale
A number of other items said to come from the collection of Ezeldeen Taha Eldarir are currently or recently for sale.
Their provenance is described in near identical terms as the British Museum shabti: bought from Salahaddin Sirmali, "authenticated and appraised" by Hossen Rashed, then imported to the US in 1948.
- An Egyptian Mummy mask dating from 700BC-30BC, is on offer for £11,807 ($15,275) online by a seller in Mexico
- A coffin lid dating back to 664BC-332BC was offered for sale by a Colorado-based art dealer, with a starting price of $65,000
- A shabti that was on sale through a Chicago-based coin dealer, dating from 1567BC-1085BC, is up for $1,950
TICKETS
Tickets start at Dh100 for adults, while children can enter free on the opening day. For more information, visit www.mubadalawtc.com.
Mercer, the investment consulting arm of US services company Marsh & McLennan, expects its wealth division to at least double its assets under management (AUM) in the Middle East as wealth in the region continues to grow despite economic headwinds, a company official said.
Mercer Wealth, which globally has $160 billion in AUM, plans to boost its AUM in the region to $2-$3bn in the next 2-3 years from the present $1bn, said Yasir AbuShaban, a Dubai-based principal with Mercer Wealth.
“Within the next two to three years, we are looking at reaching $2 to $3 billion as a conservative estimate and we do see an opportunity to do so,” said Mr AbuShaban.
Mercer does not directly make investments, but allocates clients’ money they have discretion to, to professional asset managers. They also provide advice to clients.
“We have buying power. We can negotiate on their (client’s) behalf with asset managers to provide them lower fees than they otherwise would have to get on their own,” he added.
Mercer Wealth’s clients include sovereign wealth funds, family offices, and insurance companies among others.
From its office in Dubai, Mercer also looks after Africa, India and Turkey, where they also see opportunity for growth.
Wealth creation in Middle East and Africa (MEA) grew 8.5 per cent to $8.1 trillion last year from $7.5tn in 2015, higher than last year’s global average of 6 per cent and the second-highest growth in a region after Asia-Pacific which grew 9.9 per cent, according to consultancy Boston Consulting Group (BCG). In the region, where wealth grew just 1.9 per cent in 2015 compared with 2014, a pickup in oil prices has helped in wealth generation.
BCG is forecasting MEA wealth will rise to $12tn by 2021, growing at an annual average of 8 per cent.
Drivers of wealth generation in the region will be split evenly between new wealth creation and growth of performance of existing assets, according to BCG.
Another general trend in the region is clients’ looking for a comprehensive approach to investing, according to Mr AbuShaban.
“Institutional investors or some of the families are seeing a slowdown in the available capital they have to invest and in that sense they are looking at optimizing the way they manage their portfolios and making sure they are not investing haphazardly and different parts of their investment are working together,” said Mr AbuShaban.
Some clients also have a higher appetite for risk, given the low interest-rate environment that does not provide enough yield for some institutional investors. These clients are keen to invest in illiquid assets, such as private equity and infrastructure.
“What we have seen is a desire for higher returns in what has been a low-return environment specifically in various fixed income or bonds,” he said.
“In this environment, we have seen a de facto increase in the risk that clients are taking in things like illiquid investments, private equity investments, infrastructure and private debt, those kind of investments were higher illiquidity results in incrementally higher returns.”
The Abu Dhabi Investment Authority, one of the largest sovereign wealth funds, said in its 2016 report that has gradually increased its exposure in direct private equity and private credit transactions, mainly in Asian markets and especially in China and India. The authority’s private equity department focused on structured equities owing to “their defensive characteristics.”
The rules on fostering in the UAE
A foster couple or family must:
- be Muslim, Emirati and be residing in the UAE
- not be younger than 25 years old
- not have been convicted of offences or crimes involving moral turpitude
- be free of infectious diseases or psychological and mental disorders
- have the ability to support its members and the foster child financially
- undertake to treat and raise the child in a proper manner and take care of his or her health and well-being
- A single, divorced or widowed Muslim Emirati female, residing in the UAE may apply to foster a child if she is at least 30 years old and able to support the child financially
Our legal consultant
Name: Hassan Mohsen Elhais
Position: legal consultant with Al Rowaad Advocates and Legal Consultants.
The Orwell Prize for Political Writing
Twelve books were longlisted for The Orwell Prize for Political Writing. The non-fiction works cover various themes from education, gender bias, and the environment to surveillance and political power. Some of the books that made it to the non-fiction longlist include:
- Appeasing Hitler: Chamberlain, Churchill and the Road to War by Tim Bouverie
- Some Kids I Taught and What They Taught Me by Kate Clanchy
- Invisible Women: Exposing Data Bias in a World Designed for Men by Caroline Criado Perez
- Follow Me, Akhi: The Online World of British Muslims by Hussein Kesvani
- Guest House for Young Widows: Among the Women of ISIS by Azadeh Moaveni
