A headset that delivers tiny electric pulses to the brain and is worn for just an hour a day could prove a cost-effective alternative to treating diabetes and obesity, says a medical company from Northern Ireland.
Neurovalens demonstrated its pioneering Vestal DM device on the first day of Arab Health, the region’s largest exhibition of its kind, being held at the Dubai World Trade Centre from January 24-27.
After three years of research and almost £15 million (Dh74m) of investment, the company has said the device could soon offer a non-invasive alternative to medication or brain implant surgery.
We have seen a three times more likely chance of improving diabetes by wearing the device, than without it.
Dr Jason McKeown,
Neurovalens
Dr Jason McKeown, chief executive of Neurovalens, who developed the headset during neuromodulation research at the University of California in San Diego, said the device could be used to target diabetes and metabolism through harmless electric pulses.
Neuromodulation is an area of science that stimulates nerves to produce a natural biological response, which can be done by applying small doses of stimulation directly to a specific site in the brain.
It is claimed that the Vestal DM device improves the part of the brain that protects against type two diabetes and obesity by controlling the blood sugars and appetite.
“You are putting electricity into the brainstem that controls the regulation of the body such as breathing, heart rate and blood glucose,” said Dr McKeown, the neuroscientist who has received a £2 million (Dh9m) UK government innovation grant for his research.
“If those areas are not working well, the brain requires stimulation that is usually delivered via an implant and an expensive surgery that typically costs around $30,000.
“We haven’t recreated the wheel, just reinvented a non-invasive alternative to that procedure.
“This gives a low-risk option to treat diabetes.
“We know around 1 in 5 people in the UAE have diabetes, and the same number has pre-diabetes, an early sign of the long term chronic condition.”
Around a billion people worldwide have either diabetes or pre-diabetes.
The $500 device targets the brain, spinal cord and peripheral nerves via applied electrodes by sending signals into the hypothalamus region of the brain that regulates the body’s metabolic processes like a thermostat.
The results can be tracked via a mobile app to monitor the progress.
Clinical trials
The headset requires around an hour of use each day, with users in clinical trials also reporting improved sleep patterns.
A recent 15-week trial at University College Dublin tested the device on 30 Indian patients with type two diabetes, who used it for about five hours a week over a three-month period, to see how effective it was in reducing blood sugar levels, known as HbA1c.
HbA1c, or glycated haemoglobin, develops when haemoglobin — a protein within red blood cells that carries oxygen throughout your body — joins with blood glucose.
By measuring HbA1c, doctors can analyse a patient’s blood sugar levels over time, with the higher the count, the greater the risk of developing diabetes-related complications.
The study on Indian patients reported a reduction from 7.22 per cent to 5.03 per cent over the trial.
The company is seeking US Food and Drug Administration approval, and Neurovalens hopes to show a high rate of diabetes reversal in patients with pre-type two diabetes and a 0.4 per cent reduction in their HbA1c count after 16 weeks of using the device.
Neurovalens also has separate devices under the Modius brand that can be preprogrammed to treat different ailments.
The headset devices can improve sleep and stress, with early research also showing the devices could even help reduce migraine symptoms.
“Neurological improvements take a long time, so our trials typically take place over a 24-week period to see how effective they are,” said Dr McKeown.
“Usually, once a diabetes patient stops taking their medication the reaction ceases, but with the headset, we are looking at longer-term research that may permanently improve glucose metabolism.
“We have seen a three times more likely chance of improving diabetes by wearing the device, than without it.
“Preventative medicine is a huge area of healthcare now and the current interventions available to doctors are too risky for patients with pre-diabetes.
“This is a much safer, non-invasive alternative.”
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