Jon Rahm was forced to withdraw from the Memorial Tournament in Ohio that he was leading by six strokes on Saturday after the Spaniard tested positive for Covid.
The 26-year-old's most recent test, conducted after Friday's rain-shortened second round, came back positive on Saturday and it was confirmed again while he was on the course.
PGA Tour officials informed Rahm of the test result as he left the course and the stunned former world No 1 put his hand over his face and bent over in agony and disbelief after getting the news.
"I'm very disappointed in having to withdraw from Memorial Tournament," Rahm, who is asymptomatic, said on Twitter.
"This is one of those things that happen in life, one of those moments where how we respond to a setback defines us as people. I'm very thankful that my family and I are OK."
In accordance with CDC guidelines, Rahm will need to remain in isolation until June 15 and said he planned to return to the golf course as soon as possible.
"Thank you to all of the fans for their support and I'm looking forward to watching the showdown tomorrow afternoon with you all," he said.
The PGA Tour called it "an incredibly unfortunate situation" and added that throughout the 50 events it has held since the end of last year's pandemic-induced shutdown, there have been only four positive tests within competition.
Rahm, the tournament's defending champion, was in the driver's seat at the Muirfield Village Golf Club on Saturday, where he was 18-under par and enjoyed a six-stroke advantage.
If he had gone on to win on Sunday, he would have earned $1.674 million.
With Rahm out of the picture, Americans Collin Morikawa and Patrick Cantlay are now co-leaders at 12-under par heading into the final 18 holes.
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MATCH INFO
Euro 2020 qualifier
Russia v Scotland, Thursday, 10.45pm (UAE)
TV: Match on BeIN Sports
The specs
Engine: 4.0-litre V8 twin-turbocharged and three electric motors
Power: Combined output 920hp
Torque: 730Nm at 4,000-7,000rpm
Transmission: 8-speed dual-clutch automatic
Fuel consumption: 11.2L/100km
On sale: Now, deliveries expected later in 2025
Price: expected to start at Dh1,432,000
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FIXTURES
Thu Mar 15 – West Indies v Afghanistan, UAE v Scotland
Fri Mar 16 – Ireland v Zimbabwe
Sun Mar 18 – Ireland v Scotland
Mon Mar 19 – West Indies v Zimbabwe
Tue Mar 20 – UAE v Afghanistan
Wed Mar 21 – West Indies v Scotland
Thu Mar 22 – UAE v Zimbabwe
Fri Mar 23 – Ireland v Afghanistan
The top two teams qualify for the World Cup
Classification matches
The top-placed side out of Papua New Guinea, Hong Kong or Nepal will be granted one-day international status. UAE and Scotland have already won ODI status, having qualified for the Super Six.
Thu Mar 15 – Netherlands v Hong Kong, PNG v Nepal
Sat Mar 17 – 7th-8th place playoff, 9th-10th place playoff
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Olivine: A commonly occurring magnesium iron silicate mineral that derives its name for its olive-green yellow-green colour