Bayern marked themselves as favourites to lift the trophy by crushing Barcelona 8-2 in their quarter-final when Thomas Mueller and Philippe Coutinho both scored twice.
The shockwaves are still being felt in Barcelona where both coach Quique Setien and sports director Eric Abidal have been sacked.
Following that victory, Bayern are "really hungry" for more success, says captain Manuel Neuer.
However, semi-final opponents Lyon have punched above their weight by beating Juventus and Manchester City to reach the last four.
Flick takes confidence from the "very good atmosphere" and "enormous quality in training".
"That gives you confidence in the team. I'm relaxed because, I know that they are very focused and have big goals," he said.
The Bayern boss warns "the game starts from scratch. We have to play like we did against Barcelona. Less than 100 percent will not be enough".
His side have won their last 20 matches in all competitions, securing an eighth straight Bundesliga title and lifting the German Cup in the process.
Their striker Robert Lewandowski is the Champions League's top-scorer this season on 14 goals – three short of Cristiano Ronaldo's record.
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RESULTS
5pm: Sheikh Mansour bin Zayed Al Nahyan Racing Festival Purebred Arabian Cup Conditions (PA) Dh 200,000 (Turf) 1,600m
Winner: Hameem, Adrie de Vries (jockey), Abdallah Al Hammadi (trainer)
5.30pm: Sheikha Fatima bint Mubarak Cup Conditions (PA) Dh 200,000 (T) 1,600m
Winner: Winked, Connor Beasley, Abdallah Al Hammadi
6pm: Sheikh Sultan bin Zayed Al Nahyan National Day Cup Listed (TB) Dh 380,000 (T) 1,600m
Winner: Boerhan, Ryan Curatolo, Nicholas Bachalard
6.30pm: Sheikh Sultan bin Zayed Al Nahyan National Day Group 3 (PA) Dh 500,000 (T) 1,600m
Winner: AF Alwajel, Tadhg O’Shea, Ernst Oertel
7pm: Sheikh Sultan bin Zayed Al Nahyan National Day Jewel Crown Group 1 (PA) Dh 5,000,000 (T) 2,200m
Winner: Messi, Pat Dobbs, Timo Keersmaekers
7.30pm: Sheikh Mansour bin Zayed Al Nahyan Racing Festival Handicap (PA) Dh 150,000 (T) 1,400m
Winner: Harrab, Ryan Curatolo, Jean de Roualle
8pm: Wathba Stallions Cup Handicap (PA) Dh 100,000 (T) 1,400m
Winner: AF Alareeq, Connor Beasley, Ahmed Al Mehairbi
KILLING OF QASSEM SULEIMANI
