May 7, 2019: Semi-final, second leg – Liverpool 4 Barcelona 0 (Barcelona lose 3-4 on aggregate). The result that inspired this list. Barcelona appeared destined for the final after a 3-0 win at Camp Nou, inspired by Messi’s latest masterclass – the Argentine with two goals, the second a wondrous free-kick. Barca arrived at Anfield bolstered by the fact Liverpool were missing two of the key attackers in Mohamed Salah and Roberto Firmino. What transpired was one of the most famous nights at Liverpool’s storied stadium – and not in a good way for Barcelona. Two goals apiece from Divock Origi and substitute Georginio Wijnaldum sent Liverpool to the final in Madrid and left Barcelona shell-shocked after a second successive implosion. Getty Images

Barcelona's five toughest European losses of the Lionel Messi era - in pictures