Defending champions Real Madrid suffered a 2-1 defeat at Real Betis on Saturday, which coach Carlo Ancelotti said was a "big blow" to their title defence, while Atletico Madrid took advantage to go above them in the table.
For Betis, Isco scored the winner from the penalty spot against his former side. Ancelotti picked a strong line-up, with no breathing room in the title race, despite the impending Champions League clash against rivals Atletico in midweek.
"If we play like this on Tuesday we will not win," said Ancelotti, whose side have just one win in their last five Liga matches.
The visitors took the lead at the Benito Villamarin stadium through Brahim Diaz, but Betis struck back with a Johnny Cardoso header as Real Madrid missed the suspended Jude Bellingham.
Isco secured the Andalusian side a deserved victory with a penalty early in the second half.
"It's a big blow. We have to react," continued Ancelotti. "We started well, but later we did not have the same level of commitment, the game got out of control against a side that played better than us and deserved to win."
Isco returned to action in December after missing several months with a broken leg and has hit top form in recent weeks.
"About halfway through the first half we stepped up our game, and I'm happy with the win against the best team around these days," said the playmaker, who won several major trophies with Real Madrid before departing in 2022.
Madrid started the stronger and opened the scoring after just 10 minutes, putting together a fine team move with 19 passes. It culminated when Kylian Mbappe found Ferland Mendy, who squared for Diaz to tuck home.
Betis soon found their footing and Cardoso powered a header past Thibaut Courtois from Isco's corner to level. Without Bellingham's dynamism in midfield, Madrid were outfought by a determined Betis.
Manuel Pellegrini's side took the lead early in the second half from the penalty spot when Antonio Rudiger crashed into Jesus Rodriguez as he ran in on goal.
Isco smashed home for his sixth goal across all competitions. For the final 15 minutes, Ancelotti replaced Mbappe, who had dental trouble ahead of the game, with Endrick.
"He had that (tooth) problem, he hadn't trained a lot," explained Ancelotti. "He was not at his best level."
Meanwhile, Atletico Madrid held their nerve at the Metropolitano stadium to claim an important three points. After substitute Julian Alvarez struck, Athletic Club hit the woodwork three times in the hunt for an equaliser.
"It's an incredibly important win, we knew it would not be easy," Alvarez told Movistar. "We're in the fight for the title, but we know there's a long way to go, a lot of very important games are coming close together, but with hard work and humility we'll achieve (our goals)."
Atletico goalkeeper Jan Oblak made a fine save to deny Inaki Williams early on, in an even first half. The Rojiblancos have often relied on their substitutes making huge impacts this season and so it proved again as they opened the scoring.
Simeone brought on Marcos Llorente and Alvarez just before the hour mark and the duo combined to open the scoring after 66 minutes.
Llorente delivered a fine low pass for the former Manchester City striker to run on to, and he finished with minimal fuss for his eighth league goal of the campaign.
"In the second half our changes helped us, Oblak too, and the goddess of fortune with the shots that hit the post and the bar," said Atletico coach Simeone.
MOUNTAINHEAD REVIEW
Starring: Ramy Youssef, Steve Carell, Jason Schwartzman
Director: Jesse Armstrong
Rating: 3.5/5
Surianah's top five jazz artists
Billie Holliday: for the burn and also the way she told stories.
Thelonius Monk: for his earnestness.
Duke Ellington: for his edge and spirituality.
Louis Armstrong: his legacy is undeniable. He is considered as one of the most revolutionary and influential musicians.
Terence Blanchard: very political - a lot of jazz musicians are making protest music right now.
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The biog
Favourite books: 'Ruth Bader Ginsburg: A Life' by Jane D. Mathews and ‘The Moment of Lift’ by Melinda Gates
Favourite travel destination: Greece, a blend of ancient history and captivating nature. It always has given me a sense of joy, endless possibilities, positive energy and wonderful people that make you feel at home.
Favourite pastime: travelling and experiencing different cultures across the globe.
Favourite quote: “In the future, there will be no female leaders. There will just be leaders” - Sheryl Sandberg, COO of Facebook.
Favourite Movie: Mona Lisa Smile
Favourite Author: Kahlil Gibran
Favourite Artist: Meryl Streep
The years Ramadan fell in May
Fixtures
Tuesday - 5.15pm: Team Lebanon v Alger Corsaires; 8.30pm: Abu Dhabi Storms v Pharaohs
Wednesday - 5.15pm: Pharaohs v Carthage Eagles; 8.30pm: Alger Corsaires v Abu Dhabi Storms
Thursday - 4.30pm: Team Lebanon v Pharaohs; 7.30pm: Abu Dhabi Storms v Carthage Eagles
Friday - 4.30pm: Pharaohs v Alger Corsaires; 7.30pm: Carthage Eagles v Team Lebanon
Saturday - 4.30pm: Carthage Eagles v Alger Corsaires; 7.30pm: Abu Dhabi Storms v Team Lebanon
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Killing of Qassem Suleimani
Killing of Qassem Suleimani
The specs
Engine: 1.5-litre 4-cylinder petrol
Power: 154bhp
Torque: 250Nm
Transmission: 7-speed automatic with 8-speed sports option
Price: From Dh79,600
On sale: Now
Killing of Qassem Suleimani
The Matrix Resurrections
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Stars: Keanu Reeves, Carrie-Anne Moss, Jessica Henwick
Rating:****
Know your camel milk:
Flavour: Similar to goat’s milk, although less pungent. Vaguely sweet with a subtle, salty aftertaste.
Texture: Smooth and creamy, with a slightly thinner consistency than cow’s milk.
Use it: In your morning coffee, to add flavour to homemade ice cream and milk-heavy desserts, smoothies, spiced camel-milk hot chocolate.
Goes well with: chocolate and caramel, saffron, cardamom and cloves. Also works well with honey and dates.
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KILLING OF QASSEM SULEIMANI
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Mohammed bin Zayed Majlis
Killing of Qassem Suleimani
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Engine: 77.4kW all-wheel-drive dual motor
Power: 320bhp
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The five pillars of Islam
Heavily-sugared soft drinks slip through the tax net
Some popular drinks with high levels of sugar and caffeine have slipped through the fizz drink tax loophole, as they are not carbonated or classed as an energy drink.
Arizona Iced Tea with lemon is one of those beverages, with one 240 millilitre serving offering up 23 grams of sugar - about six teaspoons.
A 680ml can of Arizona Iced Tea costs just Dh6.
Most sports drinks sold in supermarkets were found to contain, on average, five teaspoons of sugar in a 500ml bottle.
The five pillars of Islam