Jofra Archer has started a period of "intensive rehabilitation" following elbow surgery but will not know more about a potential comeback date for at least a month.
The fast bowler has been managing varying degrees of pain in his right elbow for around 18 months and finally went under the knife at the end of last week after breaking down during his first-class return for Sussex.
He will now begin his recovery programme, overseen by England, before his condition is reviewed towards the end of June.
Having already been ruled out of both New Zealand Tests, he can now be certain of missing both white-ball series versus Sri Lanka and probably the limited-overs matches against Pakistan.
England would ideally like him to be back at full throttle in time to feature in the high-profile five-Test series against India, but the Twenty20 World Cup in October and the start of the Ashes trip Down Under remain the overwhelming priority.
A statement from the ECB read: "England and Sussex seam bowler Jofra Archer had surgery to address his long-standing elbow issues on Friday.
"Archer will now commence an intensive rehabilitation period working with the ECB and Sussex medical teams. His progress will be reviewed by his consultant in approximately four weeks' time at which point further guidance will be provided as to when he can return to bowling. A further update will be given at the time."
In Archer's absence there are opportunities for other players to stake their claims, along with the established quartet of James Anderson, Stuart Broad, Chris Woakes and Mark Wood.
His Sussex team-mate Ollie Robinson is likely to make his international debut against the Kiwis, while Craig Overton and Olly Stone are also pushing their case.
Killing of Qassem Suleimani
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Our legal columnist
Name: Yousef Al Bahar
Advocate at Al Bahar & Associate Advocates and Legal Consultants, established in 1994
Education: Mr Al Bahar was born in 1979 and graduated in 2008 from the Judicial Institute. He took after his father, who was one of the first Emirati lawyers
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Our legal columnist
Name: Yousef Al Bahar
Advocate at Al Bahar & Associate Advocates and Legal Consultants, established in 1994
Education: Mr Al Bahar was born in 1979 and graduated in 2008 from the Judicial Institute. He took after his father, who was one of the first Emirati lawyers
Benefits of first-time home buyers' scheme
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In numbers: China in Dubai
The number of Chinese people living in Dubai: An estimated 200,000
Number of Chinese people in International City: Almost 50,000
Daily visitors to Dragon Mart in 2018/19: 120,000
Daily visitors to Dragon Mart in 2010: 20,000
Percentage increase in visitors in eight years: 500 per cent
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Tearful appearance
Chancellor Rachel Reeves set markets on edge as she appeared visibly distraught in parliament on Wednesday.
Legislative setbacks for the government have blown a new hole in the budgetary calculations at a time when the deficit is stubbornly large and the economy is struggling to grow.
She appeared with Keir Starmer on Thursday and the pair embraced, but he had failed to give her his backing as she cried a day earlier.
A spokesman said her upset demeanour was due to a personal matter.
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