Having an unhealthy childhood could affect the brain in later life, according to new research.
A child’s body mass index (BMI), blood pressure and physical activity levels have been linked to differences in the brain by the age of 20 – particularly the areas linked to dementia.
While it is known that a person’s health in mid-life can be a potential predictor for dementia in their later years, researchers have not previously tracked whether there could be an impact from childhood onwards.
Experts said the new study, published in the journal eBioMedicine, suggests that being unhealthy in childhood and adolescence could set the stage for later decline in brain health.
Researchers, led by a team at the University of Oxford’s Department of Psychiatry and in collaboration with University College London, examined data from 860 people who are taking part in the long-term Avon Longitudinal Study of Parents and Children.
The study is tracking people’s data over a long period of time by examining various measures linked to their health.
The academics looked at blood pressure and BMI when children were aged seven to 17, their physical activity levels when they were aged 11 to 15 and brain scans from young adulthood when they were around 20 years old.
The scientists found that markers of poorer cardiovascular health – such as higher childhood blood pressure and faster growth of BMI across teenage years – were associated with differences in the structure of a type of brain tissue called grey matter, including its thickness and surface area.
The links were particularly evident in brain regions that are known to be affected in case of dementia in old age.
Similar links between heart health and brain health have already been shown in older patients with memory difficulties and dementia, they added.
Researchers said their findings provide “preliminary evidence” that dementia risks could be identified and mitigated earlier in life.
They called for further work to look into the findings but suggested it may have implications on timings of “preventative measures”.
“Our research shows that cardiovascular health in the earliest stages of life may already be important for the structure of brain regions known to be affected in dementia in old age – much earlier than previously thought,” said lead author of the paper Holly Haines.
The co-author of the paper, Sana Suri, an associate professor from the Department of Psychiatry at the University of Oxford, added: “The findings suggest that we should be thinking about targeting modifiable lifestyle risk factors, such as obesity and exercise, decades before current lifespan models of dementia suggest.
“The early adolescent years merit greater consideration in the context of dementia prevention.”
Commenting on the paper, Dr Richard Oakley, associate director of research and innovation at the Alzheimer’s Society, said: “Dementia is the UK’s biggest killer. Although no single behaviour is guaranteed to prevent dementia, we do know there are things you can do to reduce your own risk.
“Certain factors, such as being overweight and lack of exercise between the ages of 40 to 65, are known to be linked to a higher risk of developing dementia later in life."
However, this study aimed to understand if poor cardiovascular health in childhood could increase the risk of dementia, he said.
“The study found that where being overweight, lack of exercise, and high blood pressure were present in early life, there were changes in the brain regions that could contribute to developing dementia, suggesting that it’s never too early to make healthy changes to reduce your dementia risk.”
Conflict, drought, famine
Estimates of the number of deaths caused by the famine range from 400,000 to 1 million, according to a document prepared for the UK House of Lords in 2024.
It has been claimed that the policies of the Ethiopian government, which took control after deposing Emperor Haile Selassie in a military-led revolution in 1974, contributed to the scale of the famine.
Dr Miriam Bradley, senior lecturer in humanitarian studies at the University of Manchester, has argued that, by the early 1980s, “several government policies combined to cause, rather than prevent, a famine which lasted from 1983 to 1985. Mengistu’s government imposed Stalinist-model agricultural policies involving forced collectivisation and villagisation [relocation of communities into planned villages].
The West became aware of the catastrophe through a series of BBC News reports by journalist Michael Buerk in October 1984 describing a “biblical famine” and containing graphic images of thousands of people, including children, facing starvation.
Band Aid
Bob Geldof, singer with the Irish rock group The Boomtown Rats, formed Band Aid in response to the horrific images shown in the news broadcasts.
With Midge Ure of the band Ultravox, he wrote the hit charity single Do They Know it’s Christmas in December 1984, featuring a string of high-profile musicians.
Following the single’s success, the idea to stage a rock concert evolved.
Live Aid was a series of simultaneous concerts that took place at Wembley Stadium in London, John F Kennedy Stadium in Philadelphia, the US, and at various other venues across the world.
The combined event was broadcast to an estimated worldwide audience of 1.5 billion.
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Tips to stay safe during hot weather
- Stay hydrated: Drink plenty of fluids, especially water. Avoid alcohol and caffeine, which can increase dehydration.
- Seek cool environments: Use air conditioning, fans, or visit community spaces with climate control.
- Limit outdoor activities: Avoid strenuous activity during peak heat. If outside, seek shade and wear a wide-brimmed hat.
- Dress appropriately: Wear lightweight, loose and light-coloured clothing to facilitate heat loss.
- Check on vulnerable people: Regularly check in on elderly neighbours, young children and those with health conditions.
- Home adaptations: Use blinds or curtains to block sunlight, avoid using ovens or stoves, and ventilate living spaces during cooler hours.
- Recognise heat illness: Learn the signs of heat exhaustion and heat stroke (dizziness, confusion, rapid pulse, nausea), and seek medical attention if symptoms occur.
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Tearful appearance
Chancellor Rachel Reeves set markets on edge as she appeared visibly distraught in parliament on Wednesday.
Legislative setbacks for the government have blown a new hole in the budgetary calculations at a time when the deficit is stubbornly large and the economy is struggling to grow.
She appeared with Keir Starmer on Thursday and the pair embraced, but he had failed to give her his backing as she cried a day earlier.
A spokesman said her upset demeanour was due to a personal matter.
Dark Souls: Remastered
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Born: Mukalla, Yemen, 1979
Education: UAE University, Al Ain
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Favourite piece of music: Horse Dance by Naseer Shamma
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Starring: Josh Hartnett, Saleka Shyamalan, Ariel Donaghue
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Engine: four-litre V6 and 3.5-litre V6 twin-turbo
Transmission: six-speed and 10-speed
Power: 271 and 409 horsepower
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Voices: How A Great Singer Can Change Your Life
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Key facilities
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- Premier League-standard football pitch
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