After successfully treating 30 patients with severe cases of Covid-19, Israeli scientists in Tel Aviv are hopeful their new drug can play a key role in saving lives and helping the world recover from the coronavirus pandemic.
“It’s difficult to see a patient with Covid-19 because they cannot breathe, it’s like drowning,” said Nadir Arber, who has led the study at Tel Aviv’s Ichilov Medical Centre.
“Now they can start to breathe again,” he said.
The drug developed by the team at Ichilov hospital prevents an overreaction of the immune system, which Dr Arber said affects 6 to 7 per cent of coronavirus patients.
“What we call the cytokine storm. Our immune system thinks there’s a big invasion, they’re shooting everywhere,” he said of the syndrome, which can be fatal.
Ichilov released its initial findings earlier this month, from a stage one trial of 30 patients aged between 37 and 78. All but one recovered quickly and they were discharged after four days, on average, Dr Arber said, shorter than the six-day period for coronavirus patients across Israel.
The treatment was stopped for one patient who was admitted to the intensive care unit, but she ultimately recovered.
“So this is it and now there is a huge demand from all over the world; I’m speaking to prime ministers, presidents, and this is very exciting,” said Dr Arber, who heads the hospital’s Integrated Cancer Prevention Centre.
The new drug harnesses a gene, known as CD24, that suppresses the immune system. Dr Arber has worked on the gene for 20 years.
Researchers placed CD24 on to exosomes – extremely small molecules derived from cell membranes – to develop a drug that patients can inhale.
“It goes directly to the lung. It’s sophisticated but it’s easy,” Dr Arber said.
While the initial results are promising and patients suffered no side effects, the research is in its infancy.
Phase two trials will expand the study to a few dozen patients and include a control group, while the third phase that may begin later this year will involve hundreds or potentially thousands of patients.
These broader studies will include patients internationally, although Dr Arber did not say which countries might be involved.
Greece has offered to participate in future trials of the “miracle drug”, Israeli Prime Minister Benjamin Netanyahu said Monday after separate meetings with his Greek counterpart, Kyriakos Mitsotakis, and Dr Arber.
Shiran Shapira, a doctor who runs the laboratory where the drug was developed, said she was feeling positive about the treatment’s potential.
“It’s really fast and easy to produce, and even cheap,” she said. “We were working on CD24 for two decades and with the exosomes for almost five years, so we had all the parts, and we just combined them and developed this technology.
As scientists develop new ways to treat Covid-19 and its effects, doctors have turned to existing drugs to help patients.
A UK study published in June found that dexamethasone, an anti-inflammatory steroid, cut the risk of death by more than a third among patients on ventilators.
Randy Cron, who in 2019 co-edited a book on the cytokine storm syndrome, said he predicted at the start of the pandemic that “immunosuppressive steroids are probably going to save the day”.
“Steroids aren’t a home run either, they saved maybe a third of the patients’ lives that got them, but that’s better than nothing,” he said.
The sense of urgency to tackle the pandemic and prevent patients’ immune systems going into overdrive has had one “silver lining” for Dr Cron – that people are learning about cytokine storm syndrome.
“If you don’t recognise a cytokine storm, you’re not going to treat it. And if you don’t treat it, patients are going to die,” said Dr Cron, a professor of paediatrics at the University of Alabama at Birmingham.
Aware of the grave risks of such a scenario, Bibi Ayesha, a doctor in New York, led a task force last year to identify patients at risk of developing the syndrome.
The vast majority of 288 patients included in the study were treated with steroids, while 31 were given biological treatment commonly known as antibodies.
“Biological therapy has a very narrow window,” said Dr Ayesha, a rheumatologist at Montefiore Medical Centre in New York. “If it’s [administered] early, it is proven to be beneficial.”
“There is no perfect cure, it’s the timing,” she said. She cautioned that to understand the most effective treatments, more data are needed.
“There has to be a combined effort where all these specialists can put their minds together and help the patient in a timely manner,” including rheumatologists and immunologists, she said.
Despite inoculation drives getting under way in the US, Israel and elsewhere, Dr Arber said the new drug will play an essential role in overcoming the pandemic.
“This, with vaccinations … we can go back to normal life,” he said. “We must go back to normal life.”
The Freedom Artist
By Ben Okri (Head of Zeus)
WWE Super ShowDown results
Seth Rollins beat Baron Corbin to retain his WWE Universal title
Finn Balor defeated Andrade to stay WWE Intercontinental Championship
Shane McMahon defeated Roman Reigns
Lars Sullivan won by disqualification against Lucha House Party
Randy Orton beats Triple H
Braun Strowman beats Bobby Lashley
Kofi Kingston wins against Dolph Zigggler to retain the WWE World Heavyweight Championship
Mansoor Al Shehail won the 50-man Battle Royal
The Undertaker beat Goldberg
Lexus LX700h specs
Engine: 3.4-litre twin-turbo V6 plus supplementary electric motor
Power: 464hp at 5,200rpm
Torque: 790Nm from 2,000-3,600rpm
Transmission: 10-speed auto
Fuel consumption: 11.7L/100km
On sale: Now
Price: From Dh590,000
UPI facts
More than 2.2 million Indian tourists arrived in UAE in 2023
More than 3.5 million Indians reside in UAE
Indian tourists can make purchases in UAE using rupee accounts in India through QR-code-based UPI real-time payment systems
Indian residents in UAE can use their non-resident NRO and NRE accounts held in Indian banks linked to a UAE mobile number for UPI transactions
Company profile
Date started: Founded in May 2017 and operational since April 2018
Founders: co-founder and chief executive, Doaa Aref; Dr Rasha Rady, co-founder and chief operating officer.
Based: Cairo, Egypt
Sector: Health-tech
Size: 22 employees
Funding: Seed funding
Investors: Flat6labs, 500 Falcons, three angel investors
Ferrari 12Cilindri specs
Engine: naturally aspirated 6.5-liter V12
Power: 819hp
Torque: 678Nm at 7,250rpm
Price: From Dh1,700,000
Available: Now
Global state-owned investor ranking by size
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China
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UAE
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Norway
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Canada
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Key facilities
- Olympic-size swimming pool with a split bulkhead for multi-use configurations, including water polo and 50m/25m training lanes
- Premier League-standard football pitch
- 400m Olympic running track
- NBA-spec basketball court with auditorium
- 600-seat auditorium
- Spaces for historical and cultural exploration
- An elevated football field that doubles as a helipad
- Specialist robotics and science laboratories
- AR and VR-enabled learning centres
- Disruption Lab and Research Centre for developing entrepreneurial skills
More from Neighbourhood Watch:
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1. Fasting
2. Prayer
3. Hajj
4. Shahada
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Killing of Qassem Suleimani
Results:
6.30pm: Handicap | US$135,000 (Dirt) | 1,400 metres
Winner: Rodaini, Connor Beasley (jockey), Ahmad bin Harmash (trainer)
7.05pm: Handicap | $135,000 (Turf) | 1,200m
Winner: Ekhtiyaar, Jim Crowley, Doug Watson
7.40pm: Dubai Millennium Stakes | Group 3 | $200,000 (T) | 2,000m
Winner: Spotify, James Doyle, Charlie Appleby
8.15pm: UAE Oakes | Group 3 | $250,000 (D) | 1,900m
Winner: Divine Image, William Buick, Charlie Appleby
8.50pm: Zabeel Mile | Group 2 | $250,000 (T) | 1,600m
Winner: Mythical Image, William Buick, Charlie Appleby
9.20pm: Handicap | $135,000 (T) | 1,600m
Winner: Major Partnership, Kevin Stott, Saeed bin Suroor
Company%20profile%20
%3Cp%3E%3Cstrong%3EName%3A%20%3C%2Fstrong%3EYodawy%3Cbr%3E%3Cstrong%3EBased%3A%3C%2Fstrong%3E%20Egypt%3Cbr%3E%3Cstrong%3EFounders%3A%20%3C%2Fstrong%3EKarim%20Khashaba%2C%20Sherief%20El-Feky%20and%20Yasser%20AbdelGawad%3Cstrong%3E%3Cbr%3ESector%3A%20%3C%2Fstrong%3EHealthTech%3Cbr%3E%3Cstrong%3ETotal%20funding%3A%20%3C%2Fstrong%3E%2424.5%20million%3Cbr%3E%3Cstrong%3EInvestors%3A%20%3C%2Fstrong%3EAlgebra%20Ventures%2C%20Global%20Ventures%2C%20MEVP%20and%20Delivery%20Hero%20Ventures%2C%20among%20others%3Cstrong%3E%3Cbr%3ENumber%20of%20employees%3A%3C%2Fstrong%3E%20500%3Cbr%3E%3C%2Fp%3E%0A
Living in...
This article is part of a guide on where to live in the UAE. Our reporters will profile some of the country’s most desirable districts, provide an estimate of rental prices and introduce you to some of the residents who call each area home.
Champion%20v%20Champion%20(PFL%20v%20Bellator)
%3Cp%3EHeavyweight%3A%20Renan%20Ferreira%20v%20Ryan%20Bader%20%3Cbr%3EMiddleweight%3A%20Impa%20Kasanganay%20v%20Johnny%20Eblen%3Cbr%3EFeatherweight%3A%20Jesus%20Pinedo%20v%20Patricio%20Pitbull%3Cbr%3ECatchweight%3A%20Ray%20Cooper%20III%20v%20Jason%20Jackson%3Cbr%3E%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EShowcase%20Bouts%3C%2Fstrong%3E%3Cbr%3EHeavyweight%3A%20Bruno%20Cappelozza%20(former%20PFL%20World%20champ)%20v%20Vadim%20Nemkov%20(former%20Bellator%20champ)%3Cbr%3ELight%20Heavyweight%3A%20Thiago%20Santos%20(PFL%20title%20contender)%20v%20Yoel%20Romero%20(Bellator%20title%20contender)%3Cbr%3ELightweight%3A%20Clay%20Collard%20(PFL%20title%20contender)%20v%20AJ%20McKee%20(former%20Bellator%20champ)%3Cbr%3EFeatherweight%3A%20Gabriel%20Braga%20(PFL%20title%20contender)%20v%20Aaron%20Pico%20(Bellator%20title%20contender)%3Cbr%3ELightweight%3A%20Biaggio%20Ali%20Walsh%20(pro%20debut)%20v%20Emmanuel%20Palacios%20(pro%20debut)%3Cbr%3EWomen%E2%80%99s%20Lightweight%3A%20Claressa%20Shields%20v%20Kelsey%20DeSantis%3Cbr%3EFeatherweight%3A%20Abdullah%20Al%20Qahtani%20v%20Edukondal%20Rao%3Cbr%3EAmateur%20Flyweight%3A%20Malik%20Basahel%20v%20Vinicius%20Pereira%3C%2Fp%3E%0A
2021 World Triathlon Championship Series
May 15: Yokohama, Japan
June 5: Leeds, UK
June 24: Montreal, Canada
July 10: Hamburg, Germany
Aug 17-22: Edmonton, Canada (World Triathlon Championship Final)
Nov 5-6 : Abu Dhabi, UAE
Date TBC: Chengdu, China
BULKWHIZ PROFILE
Date started: February 2017
Founders: Amira Rashad (CEO), Yusuf Saber (CTO), Mahmoud Sayedahmed (adviser), Reda Bouraoui (adviser)
Based: Dubai, UAE
Sector: E-commerce
Size: 50 employees
Funding: approximately $6m
Investors: Beco Capital, Enabling Future and Wain in the UAE; China's MSA Capital; 500 Startups; Faith Capital and Savour Ventures in Kuwait
Nepotism is the name of the game
Salman Khan’s father, Salim Khan, is one of Bollywood’s most legendary screenwriters. Through his partnership with co-writer Javed Akhtar, Salim is credited with having paved the path for the Indian film industry’s blockbuster format in the 1970s. Something his son now rules the roost of. More importantly, the Salim-Javed duo also created the persona of the “angry young man” for Bollywood megastar Amitabh Bachchan in the 1970s, reflecting the angst of the average Indian. In choosing to be the ordinary man’s “hero” as opposed to a thespian in new Bollywood, Salman Khan remains tightly linked to his father’s oeuvre. Thanks dad.
How to help
Send “thenational” to the following numbers or call the hotline on: 0502955999
2289 – Dh10
2252 – Dh 50
6025 – Dh20
6027 – Dh 100
6026 – Dh 200
Race card
5pm: Maiden (PA) Dh80,000 1,600m
5.30pm: Maiden (PA) Dh80,000 1,600m
6pm: Arabian Triple Crown Round-2 Group 3 (PA) Dh300,000 2,200m
6.30pm: Liwa Oaisi Group 2 (PA) Dh300,000 1,400m
7pm: Wathba Stallions Cup Handicap (PA) Dh70,000 1,600m
7.30pm: Handicap (TB) Dh100,000 1,600m
The National selections: 5pm: Flit Al Maury, 5.30pm: Sadah, 6pm: RB Seqondtonone, 6.30pm: RB Money To Burn, 7pm: SS Jalmood, 7.30pm: Dalaalaat
Jewel of the Expo 2020
252 projectors installed on Al Wasl dome
13.6km of steel used in the structure that makes it equal in length to 16 Burj Khalifas
550 tonnes of moulded steel were raised last year to cap the dome
724,000 cubic metres is the space it encloses
Stands taller than the leaning tower of Pisa
Steel trellis dome is one of the largest single structures on site
The size of 16 tennis courts and weighs as much as 500 elephants
Al Wasl means connection in Arabic
World’s largest 360-degree projection surface
Tuesday's fixtures
Kyrgyzstan v Qatar, 5.45pm
MATCH INFO
First Test at Barbados
West Indies won by 381 runs
Second Test at Antigua
West Indies won by 10 wickets
Third Test at St Lucia
February 9-13
Gothia Cup 2025
4,872 matches
1,942 teams
116 pitches
76 nations
26 UAE teams
15 Lebanese teams
2 Kuwaiti teams
Learn more about Qasr Al Hosn
In 2013, The National's History Project went beyond the walls to see what life was like living in Abu Dhabi's fabled fort:
Benefits of first-time home buyers' scheme
- Priority access to new homes from participating developers
- Discounts on sales price of off-plan units
- Flexible payment plans from developers
- Mortgages with better interest rates, faster approval times and reduced fees
- DLD registration fee can be paid through banks or credit cards at zero interest rates
The specs: 2018 Opel Mokka X
Price, as tested: Dh84,000
Engine: 1.4L, four-cylinder turbo
Transmission: Six-speed auto
Power: 142hp at 4,900rpm
Torque: 200Nm at 1,850rpm
Fuel economy, combined: 6.5L / 100km
TUESDAY'S ORDER OF PLAY
Centre Court
Starting at 2pm:
Elina Svitolina (UKR) [3] v Jennifer Brady (USA)
Anastasia Pavlyuchenkova (RUS) v Belinda Bencic (SUI [4]
Not before 7pm:
Sofia Kenin (USA) [5] v Elena Rybakina (KAZ)
Maria Sakkari (GRE) v Aryna Sabalenka (BLR) [7]
Court One
Starting at midday:
Karolina Muchova (CZE) v Katerina Siniakova (CZE)
Kristina Mladenovic (FRA) v Aliaksandra Sasnovich (BLR)
Veronika Kudermetova (RUS) v Dayana Yastermska (UKR)
Petra Martic (CRO) [8] v Su-Wei Hsieh (TPE)
Sorana Cirstea (ROU) v Anett Kontaveit (EST)
Chef Nobu's advice for eating sushi
“One mistake people always make is adding extra wasabi. There is no need for this, because it should already be there between the rice and the fish.
“When eating nigiri, you must dip the fish – not the rice – in soy sauce, otherwise the rice will collapse. Also, don’t use too much soy sauce or it will make you thirsty. For sushi rolls, dip a little of the rice-covered roll lightly in soy sauce and eat in one bite.
“Chopsticks are acceptable, but really, I recommend using your fingers for sushi. Do use chopsticks for sashimi, though.
“The ginger should be eaten separately as a palette cleanser and used to clear the mouth when switching between different pieces of fish.”
