A drug to treat debilitating migraines may start working immediately, unlike most treatments, a study published on Monday shows.
The medical research found people taking atogepant were less likely to have a migraine on the first day of treatment. They also had fewer migraines per week during each of the first four weeks of the study and fewer migraines during the study overall than those taking a placebo, the study published in Neurology found.
“With many current drugs to prevent migraine, it takes time to find the right dosage for the individual and it can take weeks or even months for it to be most effective,” said study author Dr Richard Lipton, from the Albert Einstein College of Medicine in New York.
“Some people give up and stop taking the drugs before they reach this point. Plus, many people experience side effects with current treatments. Developing a drug that works both effectively and quickly is critical.”
Researchers looked at data from three studies – called the Advance, Elevate and Progress trials – on the safety and effectiveness of atogepant over the first 12 weeks. Advance and Elevate involved patients with episodic migraine, meaning up to 14 migraine days a month, while Progress studied people with chronic migraine, or at least 15 days with headache per month.
“Migraine is the second-leading cause of disability in the overall population and the leading cause of disability in young women, with people reporting negative effects on their relationships, parenting, career and finances. Having a treatment that can act quickly and effectively addresses a key need,” Dr Lipton said.
On the first day of the Advance study, 12 per cent of those taking the drug had a migraine, compared to 25 per cent of those taking placebo. In the Elevate trial, it was 15 per cent and 26 per cent. For the third group, the numbers were 51 per cent and 61 per cent.
When researchers adjusted for other factors that could affect the rate of migraine, they found that people taking the drug were 61 per cent less likely to have a migraine in Advance, 47 per cent less likely in Elevate, and 37 per cent less likely in Progress. For the first two trials, the people taking atogepant had an average of one fewer day with migraine per week, compared to an average of less than half a day fewer per week for those taking the placebo.
For the third trial, average migraine days per week declined by about 1.5 days for those taking the drug compared to about one day for those taking the placebo. The people taking atogepant also showed improvement on assessments of how much migraine impaired their activities and their overall quality of life compared to people taking the placebo.
One limit of the study is that it involved mostly female and white participants, so the results may not apply to the overall population. The study was supported by AbbVie, the maker of atogepant.
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Specs
Engine: Duel electric motors
Power: 659hp
Torque: 1075Nm
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Price: On request
Avengers: Endgame
Directors: Anthony Russo, Joe Russo
Starring: Robert Downey Jr, Chris Evans, Scarlett Johansson, Chris Hemsworth, Josh Brolin
4/5 stars
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THE DEALS
Hamilton $60m x 2 = $120m
Vettel $45m x 2 = $90m
Ricciardo $35m x 2 = $70m
Verstappen $55m x 3 = $165m
Leclerc $20m x 2 = $40m
TOTAL $485m
THE BIO
Born: Mukalla, Yemen, 1979
Education: UAE University, Al Ain
Family: Married with two daughters: Asayel, 7, and Sara, 6
Favourite piece of music: Horse Dance by Naseer Shamma
Favourite book: Science and geology
Favourite place to travel to: Washington DC
Best advice you’ve ever been given: If you have a dream, you have to believe it, then you will see it.
Infiniti QX80 specs
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The National's picks
4.35pm: Tilal Al Khalediah
5.10pm: Continous
5.45pm: Raging Torrent
6.20pm: West Acre
7pm: Flood Zone
7.40pm: Straight No Chaser
8.15pm: Romantic Warrior
8.50pm: Calandogan
9.30pm: Forever Young
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10 tips for entry-level job seekers
- Have an up-to-date, professional LinkedIn profile. If you don’t have a LinkedIn account, set one up today. Avoid poor-quality profile pictures with distracting backgrounds. Include a professional summary and begin to grow your network.
- Keep track of the job trends in your sector through the news. Apply for job alerts at your dream organisations and the types of jobs you want – LinkedIn uses AI to share similar relevant jobs based on your selections.
- Double check that you’ve highlighted relevant skills on your resume and LinkedIn profile.
- For most entry-level jobs, your resume will first be filtered by an applicant tracking system for keywords. Look closely at the description of the job you are applying for and mirror the language as much as possible (while being honest and accurate about your skills and experience).
- Keep your CV professional and in a simple format – make sure you tailor your cover letter and application to the company and role.
- Go online and look for details on job specifications for your target position. Make a list of skills required and set yourself some learning goals to tick off all the necessary skills one by one.
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- Make sure you’ve set your LinkedIn profile to signal that you are “open to opportunities”. Also be sure to use LinkedIn to search for people who are still actively hiring by searching for those that have the headline “I’m hiring” or “We’re hiring” in their profile.
- Prepare for online interviews using mock interview tools. Even before landing interviews, it can be useful to start practising.
- Be professional and patient. Always be professional with whoever you are interacting with throughout your search process, this will be remembered. You need to be patient, dedicated and not give up on your search. Candidates need to make sure they are following up appropriately for roles they have applied.
Arda Atalay, head of Mena private sector at LinkedIn Talent Solutions, Rudy Bier, managing partner of Kinetic Business Solutions and Ben Kinerman Daltrey, co-founder of KinFitz
Panipat
Director Ashutosh Gowariker
Produced Ashutosh Gowariker, Rohit Shelatkar, Reliance Entertainment
Cast Arjun Kapoor, Sanjay Dutt, Kriti Sanon, Mohnish Behl, Padmini Kolhapure, Zeenat Aman
Rating 3 /5 stars
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EPL's youngest
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Living in...
This article is part of a guide on where to live in the UAE. Our reporters will profile some of the country’s most desirable districts, provide an estimate of rental prices and introduce you to some of the residents who call each area home.
