It is hoped a new malaria vaccine that tackles the infection at a different stage to those currently on offer will “significantly reduce” the number of deaths and severe cases of the disease.
The vaccine – known as RH5.1/Matrix-M – has been shown to be “safe and well tolerated” in clinical trials.
The new injection targets malaria in the “blood stage”, which comes after the plasmodium falciparum parasite that causes the deadliest form of the disease passes through the liver.
Once red blood cells become infected, symptoms such as fever and chills begin and can lead to complications including anaemia and organ failure.
Existing licensed vaccines target the liver stage of malaria – which is symptomless – and are “very effective” at stopping parasites from getting into the blood, researchers said.
But if some “slip through the net”, existing injections are not effective, experts said.
“Our goal, by targeting the blood stage of the disease with this vaccine, is to significantly reduce the number of severe cases and deaths,” Angela Minassian, associate professor in the department of biochemistry, who leads the clinical blood-stage malaria vaccine programme at the University of Oxford, said.
“The current licensed vaccines, R21/Matrix-M and RTS,S/AS01, target the liver stage of the parasite and are very effective at stopping parasites from getting into the blood.
“However, if they fail and parasites slip through the net, the disease will develop as these approved vaccines have no activity against malaria in the blood.
“Adding RH5.1/Matrix-M to these licensed vaccines should provide a vital second line of defence, achieving even higher levels of protection.
“Importantly, our study has provided the first real-world data to show that this type of vaccine works by reducing the level of parasites in the blood.”
Children participate in trials
The phase 2b trial involved 361 children, split into two groups.
One group received three doses of the RH5.1/Matrix-M vaccine and the other three doses of a rabies vaccine.
Those who had the RH5.1/Matrix-M developed high levels of antibodies against the malaria parasite, the study found.
This was more pronounced among children who had their vaccine as a newborn and at one and five months of age compared with those who had theirs as newborns and at one and two months.
Simon Draper, professor of vaccinology and translational medicine in the departments of paediatrics and biochemistry at the Kavli Institute of Nanoscience, invented the RH5.1/ Matrix-M vaccine.
“The development of an effective blood-stage malaria vaccine has proved to be an exceptionally tough scientific challenge, with previous clinical trials over a number of decades reporting no or minimal efficacy,” he said.
“These first efficacy results for a new generation of blood-stage vaccine candidates targeting the RH5 malaria protein are hugely encouraging, and represent a major milestone for the malaria field.
“We now have the exciting opportunity to test the new RH5.1 blood-stage vaccine in combination with the approved liver-stage vaccines, with the goal of developing a second-generation product that can offer very high-level efficacy against malaria disease in young African children.”
“Frequent malaria infections can impair a child’s growth and development,” Halidou Tinto, a professor of parasitology and regional director of the Institut de Recherche en Sciences de la Sante, in Burkina Faso, said.
“This trial has shown that RH5.1/Matrix-M is safe and well tolerated. No serious side effects were reported, and further stages of the trial and follow-on trials will continue to monitor the vaccine’s longer-term safety and efficacy.”
UK announces £5m programme
On Wednesday, the UK government announced a £5 million ($6.4m) programme with the RBM Partnership to End Malaria set to renew the push to end the epidemic by 2030.
The UK’s new partnership will support RBM as it brings global leaders together in the fight against malaria. This includes tackling resistance to malaria treatments and supporting efforts to control malaria in four countries: Cameroon, Nigeria, Tanzania and Uganda.
Tackling malaria will also help unlock growth in the Global South. Analysis shows reducing malaria cases by 90 per cent by 2030 could boost GDP by over $142 billion in malaria-endemic countries.
Malaria vaccine – in pictures
“Thanks to the expertise of British scientists and the efforts of partners across the world, we have shown that the malaria epidemic can be ended,” British Minister for Development Anneliese Dodds said.
“But in the Global South, too many are still losing their lives and livelihoods to the disease, with pregnant women and children especially vulnerable.
“The UK is pleased to be partnering with the RBM Partnership to End Malaria, contributing £5 million to re-energise global efforts to tackle the epidemic.
“With the right tools, treatments and leadership, we can get back on track to end malaria, save lives and unlock billions in economic growth.”
The UK’s partnership with RBM solidifies the UK as a crucial partner in global efforts to end malaria. The UK is also a leading supporter of Gavi, the Vaccine Alliance and the Global Fund to Fight AIDS, Tuberculosis and Malaria, and supports research into new tools to prevent and treat malaria.
British scientists helped develop two malaria vaccines which have the potential to save millions of lives, including the RH5.1/Matrix-M injection.
With UK support, Gavi and the Vaccine Alliance are helping roll out the new vaccines in up to 25 countries by 2025, including in Nigeria last week.
This week, Minister Dodds is in Malawi, one of three countries where the RTS,S vaccine was shown to reduce child mortality by 13 per cent.
Leading all-time NBA scorers
Kareem Abdul-Jabbar 38,387
Karl Malone 36,928
Kobe Bryant 33,643
Michael Jordan 32,292
LeBron James 31,425
Wilt Chamberlain 31,419
Specs
Engine: 51.5kW electric motor
Range: 400km
Power: 134bhp
Torque: 175Nm
Price: From Dh98,800
Available: Now
LA LIGA FIXTURES
Saturday (All UAE kick-off times)
Valencia v Atletico Madrid (midnight)
Mallorca v Alaves (4pm)
Barcelona v Getafe (7pm)
Villarreal v Levante (9.30pm)
Sunday
Granada v Real Volladolid (midnight)
Sevilla v Espanyol (3pm)
Leganes v Real Betis (5pm)
Eibar v Real Sociedad (7pm)
Athletic Bilbao v Osasuna (9.30pm)
Monday
Real Madrid v Celta Vigo (midnight)
KEY%20DATES%20IN%20AMAZON'S%20HISTORY
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UAE%20SQUAD
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Who was Alfred Nobel?
The Nobel Prize was created by wealthy Swedish chemist and entrepreneur Alfred Nobel.
- In his will he dictated that the bulk of his estate should be used to fund "prizes to those who, during the preceding year, have conferred the greatest benefit to humankind".
- Nobel is best known as the inventor of dynamite, but also wrote poetry and drama and could speak Russian, French, English and German by the age of 17. The five original prize categories reflect the interests closest to his heart.
- Nobel died in 1896 but it took until 1901, following a legal battle over his will, before the first prizes were awarded.
Honeymoonish
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COMPANY%20PROFILE
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UAE currency: the story behind the money in your pockets
Volvo ES90 Specs
Engine: Electric single motor (96kW), twin motor (106kW) and twin motor performance (106kW)
Power: 333hp, 449hp, 680hp
Torque: 480Nm, 670Nm, 870Nm
On sale: Later in 2025 or early 2026, depending on region
Price: Exact regional pricing TBA
How to keep control of your emotions
If your investment decisions are being dictated by emotions such as fear, greed, hope, frustration and boredom, it is time for a rethink, Chris Beauchamp, chief market analyst at online trading platform IG, says.
Greed
Greedy investors trade beyond their means, open more positions than usual or hold on to positions too long to chase an even greater gain. “All too often, they incur a heavy loss and may even wipe out the profit already made.
Tip: Ignore the short-term hype, noise and froth and invest for the long-term plan, based on sound fundamentals.
Fear
The risk of making a loss can cloud decision-making. “This can cause you to close out a position too early, or miss out on a profit by being too afraid to open a trade,” he says.
Tip: Start with a plan, and stick to it. For added security, consider placing stops to reduce any losses and limits to lock in profits.
Hope
While all traders need hope to start trading, excessive optimism can backfire. Too many traders hold on to a losing trade because they believe that it will reverse its trend and become profitable.
Tip: Set realistic goals. Be happy with what you have earned, rather than frustrated by what you could have earned.
Frustration
Traders can get annoyed when the markets have behaved in unexpected ways and generates losses or fails to deliver anticipated gains.
Tip: Accept in advance that asset price movements are completely unpredictable and you will suffer losses at some point. These can be managed, say, by attaching stops and limits to your trades.
Boredom
Too many investors buy and sell because they want something to do. They are trading as entertainment, rather than in the hope of making money. As well as making bad decisions, the extra dealing charges eat into returns.
Tip: Open an online demo account and get your thrills without risking real money.
Global state-owned investor ranking by size
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1.
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United States
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2.
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China
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3.
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UAE
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4.
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Japan
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5
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Norway
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6.
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Canada
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7.
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Singapore
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8.
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Australia
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9.
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Saudi Arabia
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10.
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South Korea
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DIVINE%20INTERVENTOIN
%3Cp%3EStarring%3A%20Elia%20Suleiman%2C%20Manal%20Khader%2C%20Amer%20Daher%3C%2Fp%3E%0A%3Cp%3EDirector%3A%20Elia%20Suleiman%3C%2Fp%3E%0A%3Cp%3ERating%3A%204.5%2F5%3C%2Fp%3E%0A
More on Quran memorisation:
More from Neighbourhood Watch:
UAE currency: the story behind the money in your pockets
Poacher
%3Cp%3E%3Cstrong%3EDirector%3A%20%3C%2Fstrong%3ERichie%20Mehta%26nbsp%3B%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EStarring%3A%3C%2Fstrong%3E%20Nimisha%20Sajayan%2C%20Roshan%20Mathew%2C%20Dibyendu%20Bhattacharya%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3ERating%3A%20%3C%2Fstrong%3E3%2F5%3C%2Fp%3E%0A
UAE squad
Esha Oza (captain), Al Maseera Jahangir, Emily Thomas, Heena Hotchandani, Indhuja Nandakumar, Katie Thompson, Lavanya Keny, Mehak Thakur, Michelle Botha, Rinitha Rajith, Samaira Dharnidharka, Siya Gokhale, Sashikala Silva, Suraksha Kotte, Theertha Satish (wicketkeeper) Udeni Kuruppuarachchige, Vaishnave Mahesh.
UAE tour of Zimbabwe
All matches in Bulawayo
Friday, Sept 26 – First ODI
Sunday, Sept 28 – Second ODI
Tuesday, Sept 30 – Third ODI
Thursday, Oct 2 – Fourth ODI
Sunday, Oct 5 – First T20I
Monday, Oct 6 – Second T20I
PROFILE OF SWVL
Started: April 2017
Founders: Mostafa Kandil, Ahmed Sabbah and Mahmoud Nouh
Based: Cairo, Egypt
Sector: transport
Size: 450 employees
Investment: approximately $80 million
Investors include: Dubai’s Beco Capital, US’s Endeavor Catalyst, China’s MSA, Egypt’s Sawari Ventures, Sweden’s Vostok New Ventures, Property Finder CEO Michael Lahyani
UPI facts
More than 2.2 million Indian tourists arrived in UAE in 2023
More than 3.5 million Indians reside in UAE
Indian tourists can make purchases in UAE using rupee accounts in India through QR-code-based UPI real-time payment systems
Indian residents in UAE can use their non-resident NRO and NRE accounts held in Indian banks linked to a UAE mobile number for UPI transactions
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Super Saturday results
4pm: Mahab Al Shimaal Group 3 | US$350,000 | (Dirt) | 1,200m
Winner: Drafted, Pat Dobbs (jockey), Doug Watson (trainer).
4.35pm: Al Bastakiya Listed | $300,000 | (D) | 1,900m
Winner: Divine Image, Brett Doyle, Charlie Appleby.
5.10pm: Nad Al Sheba Turf Group 3 | $350,000 | (Turf) | 1,200m
Winner: Blue Point, William Buick, Charlie Appleby.
5.45pm: Burj Nahaar Group 3 | $350,000 | (D) | 1,600m
Winner: Muntazah, Jim Crowley, Doug Watson.
6.20pm: Dubai City of Gold Group 2 | $300,000 | (T) | 2,410m
Winner: Old Persian, William Buick, Charlie Appleby.
6.55pm: Al Maktoum Challenge Round 3 Group 1 | $600,000 | (D) | 2,000m
Winner: Capezzano, Mickael Barzalona, Salem bin Ghadayer.
7.30pm: Jebel Hatta Group 1 | $400,000 | (T) | 1,800m
Winner: Dream Castle, Christophe Soumillon, Saeed bin Suroor.
ICC Women's T20 World Cup Asia Qualifier 2025, Thailand
UAE fixtures
May 9, v Malaysia
May 10, v Qatar
May 13, v Malaysia
May 15, v Qatar
May 18 and 19, semi-finals
May 20, final
