Scientists have taken a step forward in their quest to develop a vaccine for common colds by identifying a “promising target” on the virus which causes Covid-19.
It is hoped that a “pan-coronavirus” vaccine would offer some protection against new variants of the virus which causes Covid-19, as well as common colds.
Such a vaccine could provide some resilience if new coronavirus diseases emerge.
But developing this type of vaccine has proved difficult because there are a number of different coronaviruses, each with key differences which can mutate.
These mutations can reduce a person’s immunity from the virus, which leaves them vulnerable to reinfection — which is why people repeatedly have common colds and some have been infected with multiple variants of the virus which causes Covid-19 — Sars-CoV-2.
And a vaccine which targets multiple coronaviruses would need to trigger antibodies in the body which recognise and “neutralise” a range of different coronavirus.
Now researchers from the Francis Crick Institute have identified a “promising” target for such a vaccine.
The scientists found a specific area of part of the Sars-CoV-2 virus — the “S2 subunit” of the virus’s spike protein — which could potentially be targeted to help develop such a vaccine.
The Francis Crick Institute said the S2 area of the spike protein has until recently been overlooked as providing a basis for vaccination.
But this part of a coronavirus has similarities across different types of coronavirus.
Their study, published in the journal Science Translational Medicine, suggests antibodies which target this subunit appear to neutralise other coronaviruses.
The researchers found that after vaccinating mice with Sars-CoV-2 “S2”, the mice created antibodies that were able to neutralise a number of other animal and human coronaviruses.
These included the seasonal common cold coronavirus and the original strain of the virus which causes Covid-19, along with the Alpha, Beta, and Delta variants and the original Omicron variant, and two bat coronaviruses.
Kevin Ng, co-first author and a PhD student in the Retrovirus laboratory at the Crick Institute, said: “The S2 area of the spike protein is a promising target for a potential pan-coronavirus vaccine because this area is much more similar across different coronaviruses than the S1 area.
“It is less subject to mutations, and so a vaccine targeted at this area should be more robust.”
George Kassiotis, corresponding author and principal group leader at the Crick, said: “The expectation for a vaccine that targets the S2 area is that it could offer some protection against all current, as well as future, coronaviruses.
“This differs from vaccines that target the more variable S1 area which, while effective against the matching variant they are designed against, are less able to target other variants or a broad range of coronaviruses.
“There’s a lot of research still to do as we continue to test S2 antibodies against different coronaviruses and look for the most appropriate route to design and test a potential vaccine.”
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Is it worth it? We put cheesecake frap to the test.
The verdict from the nutritionists is damning. But does a cheesecake frappuccino taste good enough to merit the indulgence?
My advice is to only go there if you have unusually sweet tooth. I like my puddings, but this was a bit much even for me. The first hit is a winner, but it's downhill, slowly, from there. Each sip is a little less satisfying than the last, and maybe it was just all that sugar, but it isn't long before the rush is replaced by a creeping remorse. And half of the thing is still left.
The caramel version is far superior to the blueberry, too. If someone put a full caramel cheesecake through a liquidiser and scooped out the contents, it would probably taste something like this. Blueberry, on the other hand, has more of an artificial taste. It's like someone has tried to invent this drink in a lab, and while early results were promising, they're still in the testing phase. It isn't terrible, but something isn't quite right either.
So if you want an experience, go for a small, and opt for the caramel. But if you want a cheesecake, it's probably more satisfying, and not quite as unhealthy, to just order the real thing.
