The head of AstraZeneca has said Europe's continuing coronavirus crisis may be linked to countries choosing the wrong vaccine for their elderly populations.
Hospitals on the continent are dealing with an influx of new patients and a surge of new cases, sparking fresh lockdowns and restrictions in countries such as Austria and the Netherlands.
Pascal Soriot, the chief executive of the Cambridge-based drug maker, said he believes this may be the result of waning antibody responses, particularly in vaccines that use mRNA technology.
Following its approval, the Oxford-AstraZeneca vaccine was used to inoculate older people in Britain, but concerns over possible blood clot side-effects saw its use curtailed in much of the EU.
“When you look at the UK, there was a big peak of infections, but not so many hospitalisations relative to Europe”, he told the BBC's Today programme.
“In the UK, this vaccine was used to vaccinate older people. Whereas in Europe, initially, people thought the vaccine doesn't work in older people.”
Mr Soriot said vaccines which use mRNA technology, such as Moderna and Pfizer/BioNTech, initially generate a large antibody response, but that protection begins to decrease shortly afterwards.
By contrast, vaccines which use viral vectors, such as the Oxford-AstraZeneca vaccine, may create a strong T-cell response, which he said the “body remembers longer".
Studies show that the AstraZeneca vaccine, marketed under the Vaxzevria brand name, stimulates T-cells to a higher degree in older people, he said.
“So you see everybody's focused on antibodies, but you see them decline all time. What remains very important is the T-cell response.
“And as soon as the virus attacks you, they wake up and they come to the rescue and they defend you.
“But it takes them a little while. So you may be infected. But then they come to the rescue and you don't get hospitalised.”
Asked whether that is because of the AstraZeneca vaccine being used among older people, he added: “There’s no proof of anything, we don’t know, but we need more data to analyse this and get the answer.”
Earlier this year, the EU launched legal action against AstraZeneca over shipment delays of 200 million vaccines which threatened to derail the bloc's initial inoculation efforts.
AstraZeneca said the legal action was “without merit” before the parties agreed to the delivery of the pending vaccines in 2022.
The resulting row led to Brussels refusing to renew a contract for vaccines in June, and instead opting to buy nearly two billion doses of the Pfizer/BioNTech drug.
The WHO said Europe remains “in the firm grip” of the coronavirus pandemic, with reported daily deaths rising to almost 4,200 a day — double the number of deaths a day at the end of September.
Reported deaths from the virus have already passed the 1.5 million mark for the 53 countries that make up the WHO European region, the global health agency said.
The Netherlands on Tuesday started transporting some of its Covid-19 patients across the border to Germany to ease pressure on its hospitals.
German hospitals in total have offered 20 beds for patients from the Netherlands, after treating dozens during previous waves of the pandemic.
European countries are now racing to deliver booster shots to older and more vulnerable patients, to help stem the number of deaths as winter approaches.
However, British health authorities have not chosen to use the AstraZeneca vaccine for their booster programme, which is now being rolled out to people aged over 40.
Mr Soriot said the decision made sense as it is simpler to use one vaccine, as opposed to different vaccines.
“What is not used here is used elsewhere in the world. Different countries will make different decisions based on their circumstances”, he said.
AstraZeneca had initially decided to make its vaccine non-profit, but has revealed it will now increase pricing for developed nations while keeping costs low for poorer countries.
“But you know, we will of course adapt to every circumstance and countries that have low purchasing power will be supplied at no profit or very low price and others will be a bit more”, Mr Soriot told Sky News.
It comes as Prince Charles is set to open a new AstraZeneca research centre in Cambridge.
The £1 billion ($1.34bn) Discovery Centre, which will accommodate more than 2,200 research scientists, is located in the Cambridge Biomedical Campus.
Mr Soriot said the location of the site will make it a “fantastic place” to research new medicines.
Pharaoh's curse
British aristocrat Lord Carnarvon, who funded the expedition to find the Tutankhamun tomb, died in a Cairo hotel four months after the crypt was opened.
He had been in poor health for many years after a car crash, and a mosquito bite made worse by a shaving cut led to blood poisoning and pneumonia.
Reports at the time said Lord Carnarvon suffered from “pain as the inflammation affected the nasal passages and eyes”.
Decades later, scientists contended he had died of aspergillosis after inhaling spores of the fungus aspergillus in the tomb, which can lie dormant for months. The fact several others who entered were also found dead withiin a short time led to the myth of the curse.
The specs
Engine: 2.0-litre 4cyl turbo
Power: 261hp at 5,500rpm
Torque: 405Nm at 1,750-3,500rpm
Transmission: 9-speed auto
Fuel consumption: 6.9L/100km
On sale: Now
Price: From Dh117,059
Specs
Engine: Electric motor generating 54.2kWh (Cooper SE and Aceman SE), 64.6kW (Countryman All4 SE)
Power: 218hp (Cooper and Aceman), 313hp (Countryman)
Torque: 330Nm (Cooper and Aceman), 494Nm (Countryman)
On sale: Now
Price: From Dh158,000 (Cooper), Dh168,000 (Aceman), Dh190,000 (Countryman)
Evacuations to France hit by controversy
- Over 500 Gazans have been evacuated to France since November 2023
- Evacuations were paused after a student already in France posted anti-Semitic content and was subsequently expelled to Qatar
- The Foreign Ministry launched a review to determine how authorities failed to detect the posts before her entry
- Artists and researchers fall under a programme called Pause that began in 2017
- It has benefited more than 700 people from 44 countries, including Syria, Turkey, Iran, and Sudan
- Since the start of the Gaza war, it has also included 45 Gazan beneficiaries
- Unlike students, they are allowed to bring their families to France
Three trading apps to try
Sharad Nair recommends three investment apps for UAE residents:
- For beginners or people who want to start investing with limited capital, Mr Nair suggests eToro. “The low fees and low minimum balance requirements make the platform more accessible,” he says. “The user interface is straightforward to understand and operate, while its social element may help ease beginners into the idea of investing money by looking to a virtual community.”
- If you’re an experienced investor, and have $10,000 or more to invest, consider Saxo Bank. “Saxo Bank offers a more comprehensive trading platform with advanced features and insight for more experienced users. It offers a more personalised approach to opening and operating an account on their platform,” he says.
- Finally, StashAway could work for those who want a hands-off approach to their investing. “It removes one of the biggest challenges for novice traders: picking the securities in their portfolio,” Mr Nair says. “A goal-based approach or view towards investing can help motivate residents who may usually shy away from investment platforms.”
In The Heights
Directed by: Jon M. Chu
Stars: Anthony Ramos, Lin-Manual Miranda
Rating: ****
Greatest Royal Rumble results
John Cena pinned Triple H in a singles match
Cedric Alexander retained the WWE Cruiserweight title against Kalisto
Matt Hardy and Bray Wyatt win the Raw Tag Team titles against Cesaro and Sheamus
Jeff Hardy retained the United States title against Jinder Mahal
Bludgeon Brothers retain the SmackDown Tag Team titles against the Usos
Seth Rollins retains the Intercontinental title against The Miz, Finn Balor and Samoa Joe
AJ Styles remains WWE World Heavyweight champion after he and Shinsuke Nakamura are both counted out
The Undertaker beats Rusev in a casket match
Brock Lesnar retains the WWE Universal title against Roman Reigns in a steel cage match
Braun Strowman won the 50-man Royal Rumble by eliminating Big Cass last
Fight card
Preliminaries:
Nouredine Samir (UAE) v Sheroz Kholmirzav (UZB); Lucas Porst (SWE) v Ellis Barboza (GBR); Mouhmad Amine Alharar (MAR) v Mohammed Mardi (UAE); Ibrahim Bilal (UAE) v Spyro Besiri (GRE); Aslamjan Ortikov (UZB) v Joshua Ridgwell (GBR)
Main card:
Carlos Prates (BRA) v Dmitry Valent (BLR); Bobirjon Tagiev (UZB) v Valentin Thibaut (FRA); Arthur Meyer (FRA) v Hicham Moujtahid (BEL); Ines Es Salehy (BEL) v Myriame Djedidi (FRA); Craig Coakley (IRE) v Deniz Demirkapu (TUR); Artem Avanesov (ARM) v Badreddine Attif (MAR); Abdulvosid Buranov (RUS) v Akram Hamidi (FRA)
Title card:
Intercontinental Lightweight: Ilyass Habibali (UAE) v Angel Marquez (ESP)
Intercontinental Middleweight: Amine El Moatassime (UAE) v Francesco Iadanza (ITA)
Asian Featherweight: Zakaria El Jamari (UAE) v Phillip Delarmino (PHI)
The candidates
Dr Ayham Ammora, scientist and business executive
Ali Azeem, business leader
Tony Booth, professor of education
Lord Browne, former BP chief executive
Dr Mohamed El-Erian, economist
Professor Wyn Evans, astrophysicist
Dr Mark Mann, scientist
Gina MIller, anti-Brexit campaigner
Lord Smith, former Cabinet minister
Sandi Toksvig, broadcaster
If you go…
Emirates launched a new daily service to Mexico City this week, flying via Barcelona from Dh3,995.
Emirati citizens are among 67 nationalities who do not require a visa to Mexico. Entry is granted on arrival for stays of up to 180 days.
The schedule
December 5 - 23: Shooting competition, Al Dhafra Shooting Club
December 9 - 24: Handicrafts competition, from 4pm until 10pm, Heritage Souq
December 11 - 20: Dates competition, from 4pm
December 12 - 20: Sour milk competition
December 13: Falcon beauty competition
December 14 and 20: Saluki races
December 15: Arabian horse races, from 4pm
December 16 - 19: Falconry competition
December 18: Camel milk competition, from 7.30 - 9.30 am
December 20 and 21: Sheep beauty competition, from 10am
December 22: The best herd of 30 camels
UAE currency: the story behind the money in your pockets
Killing of Qassem Suleimani
Boulder shooting victims
• Denny Strong, 20
• Neven Stanisic, 23
• Rikki Olds, 25
• Tralona Bartkowiak, 49
• Suzanne Fountain, 59
• Teri Leiker, 51
• Eric Talley, 51
• Kevin Mahoney, 61
• Lynn Murray, 62
• Jody Waters, 65
HIJRA
Starring: Lamar Faden, Khairiah Nathmy, Nawaf Al-Dhufairy
Director: Shahad Ameen
Rating: 3/5
Company%20profile
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Killing of Qassem Suleimani
Killing of Qassem Suleimani
Indoor Cricket World Cup Dubai 2017
Venue Insportz, Dubai; Admission Free
Day 1 fixtures (Saturday)
Men 1.45pm, Malaysia v Australia (Court 1); Singapore v India (Court 2); UAE v New Zealand (Court 3); South Africa v Sri Lanka (Court 4)
Women Noon, New Zealand v South Africa (Court 3); England v UAE (Court 4); 5.15pm, Australia v UAE (Court 3); England v New Zealand (Court 4)
Killing of Qassem Suleimani
BMW M5 specs
Engine: 4.4-litre twin-turbo V-8 petrol enging with additional electric motor
Power: 727hp
Torque: 1,000Nm
Transmission: 8-speed auto
Fuel consumption: 10.6L/100km
On sale: Now
Price: From Dh650,000
Company: Instabug
Founded: 2013
Based: Egypt, Cairo
Sector: IT
Employees: 100
Stage: Series A
Investors: Flat6Labs, Accel, Y Combinator and angel investors
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%3Cp%3E%3Cstrong%3EDirectors%3A%3C%2Fstrong%3E%20Amit%20Joshi%20and%20Aradhana%20Sah%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3ECast%3A%3C%2Fstrong%3E%20Shahid%20Kapoor%2C%20Kriti%20Sanon%2C%20Dharmendra%2C%20Dimple%20Kapadia%2C%20Rakesh%20Bedi%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3ERating%3A%3C%2Fstrong%3E%204%2F5%3C%2Fp%3E%0A
The details
Heard It in a Past Life
Maggie Rogers
(Capital Records)
3/5
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%3Cp%3E%3Cstrong%3EDirector%3A%C2%A0%3C%2Fstrong%3EKelsey%20Mann%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3EStarring%3A%3C%2Fstrong%3E%C2%A0Amy%20Poehler%2C%20Maya%20Hawke%2C%20Ayo%20Edebiri%3C%2Fp%3E%0A%3Cp%3E%3Cstrong%3ERating%3A%20%3C%2Fstrong%3E4.5%2F5%3C%2Fp%3E%0A
French Touch
Carla Bruni
(Verve)
Our legal consultant
Name: Hassan Mohsen Elhais
Position: legal consultant with Al Rowaad Advocates and Legal Consultants.
Key facilities
- Olympic-size swimming pool with a split bulkhead for multi-use configurations, including water polo and 50m/25m training lanes
- Premier League-standard football pitch
- 400m Olympic running track
- NBA-spec basketball court with auditorium
- 600-seat auditorium
- Spaces for historical and cultural exploration
- An elevated football field that doubles as a helipad
- Specialist robotics and science laboratories
- AR and VR-enabled learning centres
- Disruption Lab and Research Centre for developing entrepreneurial skills
